Rome2Rio

How to get fromFlorence to Key Largoby train, plane, shuttle, bus, bus (Greyhound, Flixbus), or car

Find Transport to Key Largo

See all options

There are 9 ways to get from Florence to Key Largo by train, plane, shuttle, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Charleston International Airport, fly to Miami International Airport, shuttle

    best
    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Miami International Airport (MIA)plane plane CHS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    8h 19m
    $635–1,196

  2. Drive 713 mi

    cheapest
    1. Drive from Florence to Key Largocar car 713 mi
    11h 51m
    $131–188

  3. Train, bus

    1. Take the train from Florence Station to Miami Amtrak Stationtrain train Silver Meteor
    2. Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus bus 301
    19h 28m
    $255–503

  4. Bus

    1. Take the bus from Florence Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    3. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    21h 30m
    $147–254

  5. Train to Charleston International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CHS - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    8h 50m
    $325–1,316

  6. Bus, bus to Charlotte Douglas International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Miami International Airport (MIA)plane plane CLT - MIA
    4. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    9h 48m
    $254–555

  7. Train, bus to Wilmington International Airport, fly to Miami International Airport, shuttle

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville Bus Station to Wilmington Cape Fear Public Transitbus bus
    3. Fly from Wilmington International Airport (ILM) to Miami International Airport (MIA)plane plane ILM - MIA
    4. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    10h 4m
    $225–592

  8. Bus, bus to Charlotte Douglas International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane CLT - FLL
    4. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    10h 13m
    $219–525

  9. Train, bus to Myrtle Beach, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    4. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    10h 29m
    $308–716

Florence to Key Largo by train, foot, and bus

Calendar7Weekly Services
Duration19h 28mAverage Duration
Ticket$255Cheapest Price
See schedules

Questions & Answers

Map of how to get from Florence to Key Largo.ExpandLaunch map view
  • Distance: 648.4 mi
  • Duration: 8h 19m

What companies run services between Florence, SC, USA and Key Largo, FL, USA?

You can take a bus from Florence Bus Station to Key Largo Bus Stop via Fayetteville Bus Station, Ft Lauderdale Broward Park & Ride, and Miami Airport Station in around 21h 30m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers