There are 5 ways to get from Florence to Key West by plane, train, shuttle, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Florence Regional Airport
best- Fly from Florence Regional Airport (FLO) to Key West International Airport (EYW)plane FLO - EYW
4h 25m$86–365Train, shuttle
- Take the train from Florence Station to Miami Amtrak Stationtrain Silver Meteor
- Take a shuttle bus from Miami, FL - International Airport to Key West, FLTo the Keys
22h 50m$368–638Bus
- Take the bus from Florence Bus Station to Fayetteville Bus Stationbus
- Take the bus from Fayetteville Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
25h 1m$145–240Drive 810.1 mi
- Drive from Florence to Key Westcar 810.1 mi
14h 7m$148–214Train to Fayetteville Municipal Airport, fly
- Take the train from Florence Station to Fayetteville Amtrak Stationtrain
- Fly from Fayetteville Municipal Airport (FAY) to Key West International Airport (EYW)plane FAY - EYW
7h 3m$114–421
Florence to Key West by train, foot, tram, shuttle, and bus
Comparing Your Travel Options
The cheapest way to get from Florence to Key West is to drive which costs $140 - $220 and takes 14h 7m.
The fastest way to get from Florence to Key West is to fly which takes 4h 25m and costs $85 - $370.
No, there is no direct bus from Florence station to Key West. However, there are services departing from Florence Bus Station and arriving at N Roosevelt & 3rd Street via Fayetteville Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 25h 1m.
The distance between Florence and Key West is 685 miles. The road distance is 814.8 miles.
The best way to get from Florence to Key West without a car is to train and shuttle which takes 22h 50m and costs $360 - $650.
It takes approximately 4h 25m to get from Florence to Key West, including transfers.
Florence to Key West bus services, operated by Greyhound USA, depart from Florence Bus Station.
The best way to get from Florence to Key West is to fly which takes 4h 25m and costs $85 - $370. Alternatively, you can bus, which costs $140 - $240 and takes 25h 1m.
Florence to Key West bus services, operated by Greyhound USA, arrive at Fayetteville Bus Station.
Yes, the driving distance between Florence to Key West is 815 miles. It takes approximately 14h 7m to drive from Florence to Key West.
What companies run services between Florence, SC, USA and Key West, FL, USA?
American Airlines flies from Florence Regional Airport (FLO) to Key West International Airport (EYW) twice daily. Alternatively, you can take a bus from Florence Bus Station to N Roosevelt & 3rd Street via Fayetteville Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 25h 1m.
- Website
- aa.com
Flights from Florence Regional Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 42m
- When
- Every day
- Estimated price
- $65–340
Flights from Fayetteville Municipal Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $65–340
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Florence Station to Miami Amtrak Station
- Ave. Duration
- 15h 41m
- Frequency
- Once daily
- Estimated price
- $190–430
- Website
- Amtrak
Train from Florence Station to Fayetteville Amtrak Station
- Ave. Duration
- 1h 21m
- Frequency
- Twice daily
- Estimated price
- $21–50
- Website
- Amtrak
- Phone
- +1 (305) 289-9997
- [email protected]
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Key West, FL
- Ave. Duration
- 4h
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- Keys Shuttle
Want to know more about travelling around United States
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Booking & Getting There
Book your Florence to Key West bus tickets online with Omio.
There are 969+ hotels available in Key West.