What is the cheapest way to get from Florence to Knoxville?

The cheapest way to get from Florence to Knoxville is to drive which costs $60 - $90 and takes 5h 52m.

What is the fastest way to get from Florence to Knoxville?

The fastest way to get from Florence to Knoxville is to fly which takes 3h 54m and costs $140 - $650.

How far is it from Florence to Knoxville?

The distance between Florence and Knoxville is 282 miles. The road distance is 341.5 miles.

How long does it take to get from Florence to Knoxville?

It takes approximately 3h 54m to get from Florence to Knoxville, including transfers.

Can I drive from Florence to Knoxville?

Yes, the driving distance between Florence to Knoxville is 342 miles. It takes approximately 5h 52m to drive from Florence to Knoxville.

Where can I stay near Knoxville?

There are 279+ hotels available in Knoxville.

Florence to Knoxville - 3 ways to travel via plane, bus, shuttle, and car

How to get fromFlorence to Knoxville

Travel from

See all options

Search accommodation with Expedia

There are 3 ways to get from Florence to Knoxville by plane, bus, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly
best
1. Fly from Florence Regional Airport (FLO) to Mcghee Tyson Airport (TYS)plane FLO - TYS
3h 54m
$145–632
Drive 339.6 mi
cheapest
1. Drive from Florence to Knoxvillecar 339.6 mi
5h 52m
$62–90
Bus, shuttle, drive
1. Take the bus from Florence Bus Station to Camdenbus
2. Take the bus from Camden to Charlotte Bus Stationbus
3. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus
4. Take a shuttle bus from Boone to Black Bear Resortshuttle
5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle
6. Drive from Hot Springs to Knoxvillecar
12h 29m
$373–429

Florence Regional Airport (FLO) to Mcghee Tyson Airport (TYS) flights

8Weekly Planes

3h 58mAverage Duration

$82Cheapest Price

See schedules

Questions & Answers

Map of how to get from Florence to Knoxville.

Launch map view

Distance: 280.7 mi
Duration: 3h 54m

What companies run services between Florence, SC, USA and Knoxville, TN, USA?

American Airlines flies from Florence Regional Airport (FLO) to Mcghee Tyson Airport (TYS) once daily.

Airlines

Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.