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How to get fromFlorence to Lake Cityby bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)

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There are 6 ways to get from Florence to Lake City by bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Florence to Jacksonvillebus bus FlixBus N2472
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus Greyhound US0760S
    7h 51m
    $74–120

  2. Bus via Sumter (Greyhound)

    cheapest
    1. Take the bus from Florence Bus Station to Sumter Bus Stopbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    10h 20m
    $60–118

  3. Train, bus

    1. Take the train from Florence Station to Jacksonvilletrain train Silver Meteor
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus Greyhound US0760S
    9h
    $120–245

  4. Drive 360.3 mi

    1. Drive from Florence to Lake Citycar car 360.3 mi
    6h 5m
    $66–95

  5. Fly to Jacksonville, bus

    1. Fly from Florence Regional Airport (FLO) to Jacksonville (JAX)plane plane FLO - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 50m
    $80–402

  6. Fly to Gainesville Regional Airport, bus

    1. Fly from Florence Regional Airport (FLO) to Gainesville Regional Airport (GNV)plane plane FLO - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 59m
    $80–368

Florence to Lake City by train and bus

Calendar7Weekly Services
Duration9hAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from Florence to Lake City.ExpandLaunch map view
  • Distance: 379.8 mi
  • Duration: 7h 51m

What companies run services between Florence, SC, USA and Lake City, FL, USA?

You can take a vehicle from Florence to Lake City Bus Station via Florence and Jacksonville in around 7h 51m.

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Train operators
Bus operators

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