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How to get fromFlorence to Lancasterby train (Amtrak), bus (Greyhound, Flixbus), car, bus, plane, or train

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There are 7 ways to get from Florence to Lancaster by train (Amtrak), bus (Greyhound, Flixbus), car, bus, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Florence Station to 30th Street Stationtrain train Palmetto / ...
    2. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train Keystone Service / ...
    15h 24m
    $200–416

  2. Bus

    cheapest
    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus
    15h 50m
    $80–165

  3. Drive 503.9 mi

    1. Drive from Florence to Lancastercar car 503.9 mi
    9h 12m
    $92–133

  4. Bus, bus to Charlotte Douglas International Airport, fly to Harrisburg International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Harrisburg International Airport (MDT)plane plane CLT - MDT
    11h 8m
    $93–467

  5. Train, bus

    1. Take the train from Florence Station to Fayetteville Amtrak Stationtrain train
    2. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus
    16h 13m
    $98–191

  6. Train, bus to Myrtle Beach, fly to Harrisburg International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Harrisburg International Airport (MDT)plane plane MYR - MDT
    11h 32m
    $111–429

  7. Train, bus to Myrtle Beach, fly to Philadelphia International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Philadelphia International Airport (PHL)plane plane MYR - PHL
    4. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    12h 46m
    $155–588

Florence to Lancaster by train and bus (Amtrak)

Calendar14Weekly Services
Duration15h 24mAverage Duration
Ticket$200Cheapest Price
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Questions & Answers

Map of how to get from Florence to Lancaster.ExpandLaunch map view
  • Distance: 649 mi
  • Duration: 15h 24m

What companies run services between Florence, SC, USA and Lancaster, PA, USA?

You can take a train from Florence Station to W. Chestnut & Water St. via 30th Street Station, Elizabethtown Amtrak Station, and AMTRAK ETown in around 15h 24m. Alternatively, you can take a bus from Florence Bus Station to W. Chestnut & Water St. via Raleigh Bus Station, Washington Union Station, Harrisburg Bus Station, Harrisburg, Elizabethtown Amtrak Station, and AMTRAK ETown in around 15h 50m.

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