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How to get fromFlorence to Manhattanby bus, plane, train (Amtrak), car, train, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Florence to Manhattan by bus, plane, train (Amtrak), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Myrtle Beach, fly to Laguardia Airport

    best
    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Laguardia Airport (LGA)plane plane MYR - LGA
    5h 17m
    $115–584

  2. Bus

    cheapest
    1. Take the bus from Florence, SC to New York, NYbus bus Florence
    13h 16m
    $95–132

  3. Train (Amtrak)

    1. Take the train from Florence Station to Ny Moynihan Train Hall At Penn Stationtrain train Palmetto / ...
    12h 29m
    $350–550

  4. Drive  626.8 mi

    1. Drive from Florence to Manhattancar car 626.8 mi
    11h 4m
    $115–166

  5. Bus to Myrtle Beach, fly to Newark Liberty International Airport

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Newark Liberty International Airport (EWR)plane plane MYR - EWR
    5h 22m
    $394–660

  6. Train to Charleston International Airport, fly to Laguardia Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Laguardia Airport (LGA)plane plane CHS - LGA
    7h 8m
    $169–737

  7. Bus, bus to Charlotte Douglas International Airport, fly to Laguardia Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Laguardia Airport (LGA)plane plane CLT - LGA
    8h 2m
    $157–641

  8. Bus via Fayetteville

    1. Take the bus from Florence Bus Station to Fayetteville Bus Stationbus bus Greyhound US0642S / ...
    2. Take the bus from Fayetteville Bus Station to New York City Chinatownbus bus FlixBus N2471 / ...
    15h 6m
    $107–170

Florence to Manhattan by train (Amtrak)

Calendar14Weekly Trains
Duration12h 29mAverage Duration
Ticket$350Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to Manhattan.ExpandLaunch map view
  • Distance: 641.3 mi
  • Duration: 5h 17m

What companies run services between Florence, SC, USA and Manhattan, NY, USA?

Amtrak operates a train from Florence Station to Ny Moynihan Train Hall At Penn Station twice daily. Tickets cost $350–550 and the journey takes 12h 29m. Alternatively, Wanda Coach operates a bus from Florence, SC to New York, NY 3 times a day. Tickets cost $85–130 and the journey takes 12h.

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Bus operators

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