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How to get fromFlorence to Mayo Clinicby plane, bus, bus (Greyhound, Flixbus), train, or car

Find Transport to Mayo Clinic

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There are 6 ways to get from Florence to Mayo Clinic by plane, bus, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, bus

    best
    1. Fly from Florence Regional Airport (FLO) to Minneapolis–Saint Paul International Airport (MSP)plane plane FLO - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 33m
    $182–664

  2. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    33h 3m
    $228–421

  3. Train, bus via Milwaukee

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    36h 45m
    $463–938

  4. Drive 1,189.9 mi

    1. Drive from Florence to Mayo Cliniccar car 1,189.9 mi
    20h 57m
    $218–314

  5. Train, bus

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    38h 32m
    $524–1,088

  6. Bus, train

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    39h 21m
    $440–925

Florence to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration33h 3mAverage Duration
Ticket$228Cheapest Price
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Questions & Answers

Map of how to get from Florence to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,109 mi
  • Duration: 8h 33m

What companies run services between Florence, SC, USA and Mayo Clinic, MN, USA?

You can take a bus from Florence Bus Station to Mayo Clinic via Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 33h 3m.

Airlines
Train operators
Bus operators

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