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How to get fromFlorence to Panama City Beachby plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

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There are 7 ways to get from Florence to Panama City Beach by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Northwest Florida Beaches International Airport (ECP)plane plane FLO - ECP
    7h 1m
    $120–427

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Florence Regional Airport (FLO) to Destin–Fort Walton Beach Airport (VPS)plane plane FLO - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    7h 52m
    $85–388

  3. Bus

    1. Take the bus from Florence to Jacksonvillebus bus FlixBus N2472
    2. Take the bus from Jacksonville to Panama City Beach Bus Stationbus bus Greyhound US0760S
    13h 55m
    $114–195

  4. Train, bus via Tallahassee

    1. Take the train from Florence Station to Jacksonvilletrain train
    2. Take the bus from Jacksonville to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    14h 25m
    $159–321

  5. Drive 515.8 mi

    1. Drive from Florence to Panama City Beachcar car 515.8 mi
    9h 55m
    $95–136

  6. Train, bus

    1. Take the train from Florence Station to Jacksonvilletrain train Silver Meteor
    2. Take the bus from Jacksonville to Panama City Beach Bus Stationbus bus Greyhound US0760S
    15h 5m
    $159–321

  7. Bus via Sumter (Greyhound)

    1. Take the bus from Florence Bus Station to Sumter Bus Stopbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Panama City Beach Bus Stationbus bus
    16h 24m
    $100–193

Florence Regional Airport (FLO) to Northwest Florida Beaches International Airport (ECP) flights

Calendar22Weekly Planes
Duration9h 37mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Florence to Panama City Beach.ExpandLaunch map view
  • Distance: 463.7 mi
  • Duration: 7h 1m

What companies run services between Florence, SC, USA and Panama City Beach, FL, USA?

American Airlines flies from Florence Regional Airport (FLO) to Northwest Florida Beaches International Airport (ECP) 3 times a day. Alternatively, you can take a vehicle from Florence to Panama City Beach via Florence, Jacksonville, and Panama City Beach Bus Station in around 13h 55m.

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