Rome2Rio

How to get fromFlorence to Pittsburghby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

Find Transport to Pittsburgh

See all options

There are 6 ways to get from Florence to Pittsburgh by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Pittsburgh International Airport (PIT)plane plane FLO - PIT
    5h
    $80–432

  2. Bus

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Pittsburgh Intermodal Stationbus bus
    15h 35m
    $102–174

  3. Train (Amtrak)

    1. Take the train from Florence Station to Richmond Staples Mill Road Amtrak Stationtrain train Palmetto / ...
    2. Take the train from Richmond Staples Mill Road Amtrak Station to Pittsburgh Amtrak Stationtrain train Floridian
    17h 25m
    $385–593

  4. Drive  545.2 mi

    1. Drive from Florence to Pittsburghcar car 545.2 mi
    9h 55m
    $100–144

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Pittsburgh International Airport (PIT)plane plane MYR - PIT
    5h 45m
    $193–782

  6. Bus, train

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus Greyhound US0642S / ...
    2. Take the train from Raleigh Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    19h 12m
    $351–543

Florence to Pittsburgh by bus

Calendar14Weekly Buses
Duration15h 35mAverage Duration
Ticket$102Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Florence to Pittsburgh.ExpandLaunch map view
  • Distance: 464.1 mi
  • Duration: 5h

What companies run services between Florence, SC, USA and Pittsburgh, PA, USA?

American Airlines flies from Florence Regional Airport (FLO) to Pittsburgh International Airport (PIT) 3 times a day. Alternatively, you can take a bus from Florence Bus Station to Pittsburgh Intermodal Station via Raleigh Bus Station and Washington Union Station in around 15h 35m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There