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How to get fromFlorence to Port Saint Lucieby plane, taxi, bus (Flixbus), train, bus, car, or bus (Greyhound)

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There are 6 ways to get from Florence to Port Saint Lucie by plane, taxi, bus (Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Vero Beach Municipal Airport, taxi

    best
    1. Fly from Florence Regional Airport (FLO) to Vero Beach Municipal Airport (VRB)plane plane FLO - VRB
    2. Take the taxi from Vero Beach Municipal Airport (VRB) to Port Saint Lucietaxi taxi
    6h 54m
    $185–592

  2. Bus via Jacksonville (Greyhound)

    cheapest
    1. Take the bus from Florence Bus Station to Sumter Bus Stopbus bus
    2. Take the bus from Sumter Bus Stop to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Port St Luciebus bus
    17h 4m
    $86–176

  3. Bus (Flixbus)

    1. Take the bus from Florence to Orlando Bus Stationbus bus FlixBus N2472
    2. Take the bus from Orlando Bus Station to Port St Luciebus bus FlixBus N2401 / ...
    13h 20m
    $106–173

  4. Train, bus

    1. Take the train from Florence Station to Kissimmee Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus Orlando to Miami
    13h 55m
    $194–376

  5. Drive 540.7 mi

    1. Drive from Florence to Port Saint Luciecar car 540.7 mi
    8h 55m
    $99–143

  6. Fly to President Donald J. Trump International Airport, bus

    1. Fly from Florence Regional Airport (FLO) to President Donald J. Trump International Airport (PBI)plane plane FLO - PBI
    2. Take the bus from West Palm Beach Bus Station to Port St Luciebus bus
    10h 10m
    $99–458

Florence to Port Saint Lucie by train and bus

Calendar7Weekly Services
Duration13h 55mAverage Duration
Ticket$194Cheapest Price
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Questions & Answers

Map of how to get from Florence to Port Saint Lucie.ExpandLaunch map view
  • Distance: 483.1 mi
  • Duration: 6h 54m

What companies run services between Florence, SC, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Florence to SW PSL Blvd & SE Bayshore Blvd via Florence, Orlando Bus Station, and SW Gatlin Blvd & SW Brescia St in around 13h 20m.

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