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How to get fromFlorence to Portlandby plane, train, bus, bus (Flixbus, Amtrak), car, or bus (Greyhound, Amtrak)

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There are 5 ways to get from Florence to Portland by plane, train, bus, bus (Flixbus, Amtrak), car, or bus (Greyhound, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Florence Regional Airport (FLO) to Portland (PWM)plane plane FLO - PWM
    6h 12m
    $110–502

  2. Train, bus

    1. Take the train from Florence Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    3. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    19h 12m
    $293–621

  3. Bus

    1. Take the bus from Florence, SC to New York, NYbus bus
    2. Take the bus from NYC Downtown to Bostonbus bus
    3. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    20h 9m
    $140–226

  4. Drive 928.9 mi

    1. Drive from Florence to Portlandcar car 928.9 mi
    16h 35m
    $170–245

  5. Bus via Raleigh

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Bostonbus bus
    4. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    21h 34m
    $154–313

Florence to Portland by train and bus

Calendar14Weekly Services
Duration19h 12mAverage Duration
Ticket$293Cheapest Price
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Questions & Answers

Map of how to get from Florence to Portland.ExpandLaunch map view
  • Distance: 827.5 mi
  • Duration: 6h 12m

What companies run services between Florence, SC, USA and Portland, ME, USA?

American Airlines flies from Florence Regional Airport (FLO) to Portland (PWM) twice daily. Alternatively, you can take a bus from Florence, SC to Portland, ME via New York, NY, NYC Downtown, Boston, and Boston, MA - South Station in around 20h 9m.

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