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How to get fromFlorence to Sanibel Islandby plane, bus (Flixbus), train, bus, or car

Find Transport to Sanibel Island

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There are 5 ways to get from Florence to Sanibel Island by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Florence Regional Airport (FLO) to Ft. Myers (RSW)plane plane FLO - RSW
    5h 48m
    $165–522

  2. Drive 616.4 mi

    cheapest
    1. Drive from Florence to Sanibel Islandcar car 616.4 mi
    10h 56m
    $113–163

  3. Bus (Flixbus)

    1. Take the bus from Florence to Orlando Bus Stationbus bus FlixBus N2472
    2. Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus bus FlixBus 2421
    16h 35m
    $161–251

  4. Train, bus (Amtrak)

    1. Take the train from Florence Station to Orlandotrain train Silver Meteor
    2. Take the bus from Orlando to Fort Myers Amtrak Bus Stopbus bus Amtrak Thruway Connecting Service
    17h 6m
    $295–523

  5. Train, bus via Kissimmee

    1. Take the train from Florence Station to Kissimmee Amtrak Stationtrain train Silver Meteor
    2. Take the bus from Orlando to Fort Myers Bus Stopbus bus FlixBus 2421
    19h 53m
    $243–453

Florence Regional Airport (FLO) to Ft. Myers (RSW) flights

Calendar19Weekly Planes
Duration6h 40mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Florence to Sanibel Island.ExpandLaunch map view
  • Distance: 569.2 mi
  • Duration: 5h 48m

What companies run services between Florence, SC, USA and Sanibel Island, FL, USA?

American Airlines flies from Florence Regional Airport (FLO) to Ft. Myers (RSW) 3 times a day. Alternatively, you can take a vehicle from Florence to Sanibel Island via Florence, Orlando Bus Station, Rosa Parks Transportation Ctr, and Cape Coral Transfer Center in around 16h 35m.

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