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How to get fromFlorence to Siesta Keyby plane, train, car, bus (Flixbus), or bus

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There are 5 ways to get from Florence to Siesta Key by plane, train, car, bus (Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Florence Regional Airport (FLO) to Sarasota–Bradenton International Airport (SRQ)plane plane FLO - SRQ
    6h 59m
    $122–666

  2. Drive  552 mi

    cheapest
    1. Drive from Florence to Siesta Keycar car 552 mi
    9h 33m
    $101–146

  3. Train, drive (Amtrak)

    1. Take the train from Florence Station to Kissimmee Amtrak Stationtrain train
    2. Take the train from Kissimmee Amtrak Station to Tampatrain train
    3. Drive from Tampa to Siesta Keycar car
    14h 21m
    $164–356

  4. Bus (Flixbus)

    1. Take the bus from Florence to Orlando Bus Stationbus bus FlixBus N2472
    2. Take the bus from Orlando Bus Station to Sarasota Cattlemen Transfer Centerbus bus FlixBus 2421
    14h 42m
    $103–165

  5. Train, Amtrak Thruway (Amtrak)

    1. Take the train from Florence Station to Orlandotrain train Silver Meteor
    2. Take the bus from Orlando, FL to Sarasota Amtrak Bus Stopbus bus Amtrak Thruway Connecting Service
    16h 20m
    $175–355

Florence to Siesta Key by train and bus (Amtrak)

Calendar7Weekly Services
Duration16h 20mAverage Duration
Ticket$175Cheapest Price
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Questions & Answers

Map of how to get from Florence to Siesta Key.ExpandLaunch map view
  • Distance: 516.1 mi
  • Duration: 6h 59m

What companies run services between Florence, SC, USA and Siesta Key, FL, USA?

American Airlines flies from Florence Regional Airport (FLO) to Sarasota–Bradenton International Airport (SRQ) twice daily. Alternatively, you can take a vehicle from Florence to Ocean Blvd @ Avenida Madera via Florence, Orlando Bus Station, Sarasota Cattlemen Transfer Center, and Cattlemen Transit Station in around 14h 42m.

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