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How to get fromFlorence to St. Louisby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Find Transport to St. Louis

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There are 5 ways to get from Florence to St. Louis by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Florence Regional Airport

    best
    1. Fly from Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL)plane plane FLO - STL
    4h 45m
    $108–565

  2. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    18h 1m
    $140–231

  3. Train (Amtrak)

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    33h 14m
    $788–1,267

  4. Drive  819.6 mi

    1. Drive from Florence to St. Louiscar car 819.6 mi
    13h 48m
    $145–210

  5. Bus to Myrtle Beach, fly

    1. Take the bus from Florence Bus Station to Myrtle Beach Bus Stationbus bus
    2. Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane plane MYR - STL
    5h 39m
    $116–525

Florence to St. Louis by bus

Calendar12Weekly Buses
Duration18h 1mAverage Duration
Ticket$140Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florence to St. Louis.ExpandLaunch map view
  • Distance: 684.9 mi
  • Duration: 4h 45m

What companies run services between Florence, SC, USA and St. Louis, MO, USA?

American Airlines flies from Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL) 3 times a day. Alternatively, you can take a bus from Florence Bus Station to St Louis Bus Station via Atlanta Bus Station in around 18h 1m.

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