There are 4 ways to get from Florence, SC to Saint Louis County by plane, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Florence Regional Airport
best- Fly from Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL)plane FLO - STL
6h$123–576Drive to Myrtle Beach, fly
cheapest- Drive from Florence, SC to Myrtle Beach (MYR)car
- Fly from Myrtle Beach (MYR) to Lambert–St. Louis International Airport (STL)plane MYR - STL
5h 8m$112–522Bus
- Take the bus from Florence Bus Station to Atlanta Bus Stationbus Greyhound US0641S / ...
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus Greyhound US0186
21h 5m$148–275Drive 832.6 mi
- Drive from Florence, SC to Saint Louis Countycar 832.6 mi
13h 59m$152–220
Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Florence, SC to Saint Louis County is to bus which costs $140 - $280 and takes 21h 5m.
The fastest way to get from Florence, SC to Saint Louis County is to drive and fly which takes 5h 8m and costs $110 - $550.
No, there is no direct bus from Florence, SC station to Saint Louis County. However, there are services departing from Florence Bus Station and arriving at Clayton @ Ballas Wb via Atlanta Bus Station and Clayton Transit Center. The journey, including transfers, takes approximately 21h 5m.
The distance between Florence, SC and Saint Louis County is 697 miles. The road distance is 837.4 miles.
The best way to get from Florence, SC to Saint Louis County without a car is to bus which takes 21h 5m and costs $140 - $280.
It takes approximately 6h to get from Florence, SC to Saint Louis County, including transfers.
Florence, SC to Saint Louis County bus services, operated by Greyhound USA, depart from Florence Bus Station.
The best way to get from Florence, SC to Saint Louis County is to fly which takes 6h and costs $120 - $600. Alternatively, you can bus, which costs $140 - $280 and takes 21h 5m.
Florence, SC to Saint Louis County bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Saint Louis County is 1h behind Florence, SC. It is currently 11:50 AM in Florence, SC and 10:50 AM in Saint Louis County.
What companies run services between Florence, SC, USA and Saint Louis County, MO, USA?
American Airlines flies from Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL) 6 times a week. Alternatively, you can take a vehicle from Florence, SC to Clayton @ Ballas Wb via Florence Bus Station, Atlanta Bus Station, St Louis Bus Station, CIVIC CENTER station, CLAYTON station, and Clayton Transit Center in around 21h 5m.
- Website
- southwest.com
Flights from Myrtle Beach to Lambert–St. Louis International Airport
- Ave. Duration
- 2h 5m
- When
- Saturday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $95–500
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 4h 23m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $100–550
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 4h 30m
- When
- Tuesday and Wednesday
- Estimated price
- $120–600
- Website
- aa.com
Flights from Florence Regional Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 4h 54m
- When
- Sunday, Monday, Thursday, Friday, and Saturday
- Estimated price
- $100–550
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $100–500
- Website
- delta.com
Flights from Myrtle Beach to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $100–550
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Florence Bus Station to Atlanta Bus Station
- Ave. Duration
- 6h 40m
- Frequency
- 4 times a day
- Estimated price
- $45–85
- Website
- Greyhound
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Twice daily
- Estimated price
- $85–170
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 21m
- Frequency
- Once daily
- Estimated price
- $90–150
- Schedules at
- Flixbus USA
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More Questions & Answers
Yes, the driving distance between Florence, SC to Saint Louis County is 837 miles. It takes approximately 13h 59m to drive from Florence, SC to Saint Louis County.
There are 458+ hotels available in Saint Louis County.



