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How to get fromFlorence Station to Chicagoby train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

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There are 11 ways to get from Florence Station to Chicago by train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Charleston International Airport, fly to Chicago Midway International Airport

    best
    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    7h 11m
    $112–451

  2. Bus, bus to Charlotte Douglas International Airport, fly to Chicago Midway International Airport

    cheapest
    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Chicago Midway International Airport (MDW)plane plane CLT - MDW
    8h 32m
    $104–488

  3. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S / ...
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    24h 4m
    $155–296

  4. Train (Amtrak)

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train Palmetto / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    27h 28m
    $377–778

  5. Drive 843.8 mi

    1. Drive from Florence Station to Chicagocar car 843.8 mi
    15h 15m
    $154–223

  6. Bus, bus to Charlotte Douglas International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to Chicago O'Hare International Airport (ORD)plane plane CLT - ORD
    8h 54m
    $144–458

  7. Train, bus to Myrtle Beach, fly to Chicago Midway International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    8h 41m
    $124–460

  8. Bus, bus to Columbia, fly to Chicago O'Hare International Airport

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Columbia, SCbus bus
    3. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)plane plane CAE - ORD
    9h 31m
    $171–813

  9. Train, bus to Myrtle Beach, fly to Chicago O'Hare International Airport

    1. Take the train from Florence Station to Charleston Amtrak Stationtrain train
    2. Take the bus from Charleston Bus Station to Myrtle Beach Bus Stationbus bus
    3. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    9h 11m
    $114–410

  10. Bus, bus to Charlotte Douglas International Airport, fly to South Bend, train

    1. Take the bus from Florence Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Fly from Charlotte Douglas International Airport (CLT) to South Bend (SBN)plane plane CLT - SBN
    4. Take the train from South Bend Airport to Van Buren St.train train
    10h 52m
    $145–708

  11. Bus, train

    1. Take the bus from Florence Bus Station to Raleigh Bus Stationbus bus Greyhound US0642S / ...
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train Floridian
    29h 40m
    $365–796

Florence Station to Chicago by train (Amtrak)

Calendar7Weekly Trains
Duration27h 28mAverage Duration
Ticket$377Cheapest Price
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Questions & Answers

Map of how to get from Florence Station to Chicago.ExpandLaunch map view
  • Distance: 858.3 mi
  • Duration: 7h 11m

What companies run services between Florence Station, SC, USA and Chicago, IL, USA?

You can take a vehicle from Florence Station to Chicago Bus Station via Florence Bus Station and Atlanta Bus Station in around 24h 4m. Alternatively, you can take a train from Florence Station to Chicago Union Station via Petersburg Amtrak Station in around 27h 28m.

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