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How to get fromFlorence Station to St. Louisby plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, or bus (Greyhound, Flixbus)

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There are 5 ways to get from Florence Station to St. Louis by plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL)plane plane FLO - STL
    5h 13m
    $113–565

  2. Bus via Carbondale

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    19h 20m
    $130–250

  3. Train (Amtrak)

    1. Take the train from Florence Station to Petersburg Amtrak Stationtrain train
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    33h 14m
    $466–967

  4. Drive 819.9 mi

    1. Drive from Florence Station to St. Louiscar car 819.9 mi
    13h 49m
    $150–217

  5. Bus

    1. Take the bus from Florence Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 44m
    $125–245

Florence Station to St. Louis by train (Amtrak)

Calendar7Weekly Trains
Duration33h 14mAverage Duration
Ticket$466Cheapest Price
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Questions & Answers

Map of how to get from Florence Station to St. Louis.ExpandLaunch map view
  • Distance: 684.8 mi
  • Duration: 5h 13m

What companies run services between Florence Station, SC, USA and St. Louis, MO, USA?

American Airlines flies from Florence Regional Airport (FLO) to Lambert–St. Louis International Airport (STL) 6 times a week. Alternatively, you can take a vehicle from Florence Station to St Louis Bus Station via Florence Bus Station, Atlanta Bus Station, and Carbondale Intermodal Station in around 19h 20m.

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