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How to get fromFlorida Keys to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

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There are 8 ways to get from Florida Keys to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Key West International Airport to Jacksonville

    best
    1. Fly from Key West International Airport (EYW) to Jacksonville (JAX)plane plane EYW - JAX
    8h 23m
    $453–917

  2. Bus

    cheapest
    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport Station to Jacksonvillebus bus FlixBus 2431
    14h 48m
    $82–164

  3. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the train from Hollywood Amtrak Station to Jacksonvilletrain train Silver Meteor / ...
    16h 18m
    $156–323

  4. Drive 487.4 mi

    1. Drive from Florida Keys to Jacksonvillecar car 487.4 mi
    8h 45m
    $89–129

  5. Shuttle to Miami International Airport, fly to Jacksonville

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Jacksonville (JAX)plane plane MIA - JAX
    8h 30m
    $203–497

  6. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Jacksonville

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Jacksonville (JAX)plane plane FLL - JAX
    8h 54m
    $293–957

  7. Fly Key West International Airport to Orlando Sanford, drive

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    6h 9m
    $154–419

  8. Shuttle, bus

    1. Take a shuttle bus from Summerland Key - Mote Marine Lab to Fort Lauderdale, FL - International Airportshuttle bus
    2. Take the bus from Fort Lauderdale International Airport to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    17h 25m
    $249–339

Florida Keys to Jacksonville by foot and bus

Calendar15Weekly Services
Duration14h 48mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Florida Keys to Jacksonville.ExpandLaunch map view
  • Distance: 463.7 mi
  • Duration: 8h 23m

What companies run services between Florida Keys, FL, USA and Jacksonville, FL, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Jacksonville (JAX) every 4 hours. Alternatively, you can take a vehicle from Florida Keys to Jacksonville via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, and Miami Airport Station in around 14h 48m.

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