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How to get fromFlorida Keys to Jacksonvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

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There are 7 ways to get from Florida Keys to Jacksonville by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Key West International Airport

    best
    1. Fly from Key West International Airport (EYW) to Jacksonville (JAX)plane plane EYW - JAX
    7h 58m
    $443–917

  2. Bus

    cheapest
    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport Station to Jacksonvillebus bus FlixBus 2431 / ...
    15h 13m
    $75–159

  3. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    3. Take the train from Fort Lauderdale Amtrak Station to Jacksonvilletrain train
    16h 16m
    $135–288

  4. Drive 487.4 mi

    1. Drive from Florida Keys to Jacksonvillecar car 487.4 mi
    8h 45m
    $89–129

  5. Shuttle to Miami International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Jacksonville (JAX)plane plane MIA - JAX
    8h 30m
    $203–527

  6. Shuttle to Fort Lauderdale–Hollywood International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Jacksonville (JAX)plane plane FLL - JAX
    8h 58m
    $293–757

  7. Shuttle, bus

    1. Take a shuttle bus from Summerland Key - Mote Marine Lab to Fort Lauderdale, FL - International Airportshuttle bus
    2. Take the bus from Fort Lauderdale International Airport to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    18h 5m
    $242–324

Florida Keys to Jacksonville by foot and bus

Calendar19Weekly Services
Duration15h 13mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Florida Keys to Jacksonville.ExpandLaunch map view
  • Distance: 463.7 mi
  • Duration: 7h 58m

What companies run services between Florida Keys, FL, USA and Jacksonville, FL, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Jacksonville (JAX) every 4 hours. Alternatively, you can take a vehicle from Florida Keys to Jacksonville via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, and Miami Airport Station in around 15h 13m.

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