There are 5 ways to get from Florida Keys to Mechanicsburg by plane, bus (Greyhound, Flixbus), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Harrisburg International Airport
best- Fly from Key West International Airport (EYW) to Harrisburg International Airport (MDT)plane EYW - MDT
9h 24m$189–548Bus
- Take the bus from Big Pine Key to Miami Airport Stationbus
- Take the bus from Miami to Washington Union Stationbus
- Take the bus from Washington Union Station to Harrisburg Bus Stationbus
33h 28m$224–387Bus, train
- Take the bus from Big Pine Key to Miami Airport Stationbus
- Take the train from Miami Amtrak Station to 30th Street Stationtrain
- Take the train from 30th Street Station to Harrisburgtrain
36h 21m$491–989Drive 1,293.9 mi
- Drive from Florida Keys to Mechanicsburgcar 1,293.9 mi
22h 27m$237–342Fly to Philadelphia International Airport, train
- Fly from Key West International Airport (EYW) to Philadelphia International Airport (PHL)plane EYW - PHL
- Take the train from 30th Street Station to Harrisburgtrain
10h 22m$256–839
Florida Keys to Mechanicsburg by foot, bus, and taxi
Questions & Answers
The cheapest way to get from Florida Keys to Mechanicsburg is to bus which costs $220 - $390 and takes 33h 28m.
The fastest way to get from Florida Keys to Mechanicsburg is to fly which takes 9h 24m and costs $180 - $550.
No, there is no direct bus from Florida Keys to Mechanicsburg. However, there are services departing from Sugarloaf Key - Lower - Opposite Sugarloaf Lodge and arriving at E Main St & Arch St WB via Big Pine Key, Miami, Washington Union Station and Market Square Transfer Center. The journey, including transfers, takes approximately 33h 28m.
The distance between Florida Keys and Mechanicsburg is 1180 miles. The road distance is 1301.4 miles.
The best way to get from Florida Keys to Mechanicsburg without a car is to bus which takes 33h 28m and costs $220 - $390.
It takes approximately 9h 24m to get from Florida Keys to Mechanicsburg, including transfers.
Florida Keys to Mechanicsburg bus services, operated by Greyhound USA, depart from Big Pine Key station.
The best way to get from Florida Keys to Mechanicsburg is to fly which takes 9h 24m and costs $180 - $550. Alternatively, you can bus, which costs $220 - $390 and takes 33h 28m.
Florida Keys to Mechanicsburg bus services, operated by Greyhound USA, arrive at Miami Airport Station.
Yes, the driving distance between Florida Keys to Mechanicsburg is 1301 miles. It takes approximately 22h 27m to drive from Florida Keys to Mechanicsburg.
What companies run services between Florida Keys, FL, USA and Mechanicsburg, Cumberland County, PA, USA?
United Airlines, Delta, and American Airlines fly from Key West International Airport (EYW) to Harrisburg International Airport (MDT) every 4 hours. Alternatively, you can take a vehicle from Florida Keys to E Main St & Arch St WB via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami, Airport Intermodal Station, Miami, Washington Union Station, Harrisburg Bus Station, and Market Square Transfer Center in around 33h 28m.
- Website
- aa.com
Flights from Key West International Airport to Harrisburg International Airport via Charlotte
- Ave. Duration
- 6h 19m
- When
- Every day
- Estimated price
- $95–440
Flights from Key West International Airport to Harrisburg International Airport via Philadelphia International Airport
- Ave. Duration
- 7h 12m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $100–450
Flights from Key West International Airport to Harrisburg International Airport via Boston
- Ave. Duration
- 9h 29m
- When
- Saturday
- Estimated price
- $130–550
Flights from Key West International Airport to Harrisburg International Airport via Miami
- Ave. Duration
- 10h 19m
- When
- Saturday
- Estimated price
- $95–440
Flights from Key West International Airport to Philadelphia International Airport
- Ave. Duration
- 3h 11m
- When
- Every day
- Estimated price
- $130–650
Flights from Key West International Airport to Philadelphia International Airport via Miami
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $130–650
- Website
- delta.com
Flights from Key West International Airport to Harrisburg International Airport via Atlanta
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $100–460
- Website
- united.com
Flights from Key West International Airport to Harrisburg International Airport via Washington Dulles
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $95–430
Flights from Key West International Airport to Philadelphia International Airport via Washington Dulles
- Ave. Duration
- 5h 28m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–650
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Miami Amtrak Station to 30th Street Station
- Ave. Duration
- 26h 15m
- Frequency
- Once daily
- Estimated price
- $420–850
- Website
- https://www.amtrak.com/home.html
Train from 30th Street Station to Harrisburg
- Ave. Duration
- 1h 51m
- Frequency
- Every 2 hours
- Estimated price
- $30–70
- Website
- https://www.amtrak.com/home.html
Train from 30th Street Station to Harrisburg
- Ave. Duration
- 1h 51m
- Frequency
- Every 2 hours
- Estimated price
- $30–70
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $20–40
- Website
- https://www.greyhound.com/
Bus from Washington Union Station to Harrisburg Bus Station
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–35
- Website
- https://www.greyhound.com/
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $20–40
- Website
- https://www.greyhound.com/
- Website
- greyhound.com
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Bus from Washington Union Station to Harrisburg Bus Station
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Schedules at
- greyhound.com
Bus from Big Pine Key to Miami Airport Station
- Ave. Duration
- 3h 35m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Miami to Washington Union Station
- Ave. Duration
- 22h 5m
- Frequency
- 4 times a week
- Estimated price
- $170–290
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
There are 163+ hotels available in Mechanicsburg.






