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How to get fromFlorida Keys to Mechanicsburgby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 5 ways to get from Florida Keys to Mechanicsburg by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Key West International Airport (EYW) to Harrisburg International Airport (MDT)plane plane EYW - MDT
    9h 24m
    $189–588

  2. Bus

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Harrisburg Bus Stationbus bus
    32h 12m
    $216–331

  3. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Amtrak Station to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Harrisburgtrain train
    36h 21m
    $799–1,254

  4. Drive  1,293.9 mi

    1. Drive from Florida Keys to Mechanicsburgcar car 1,293.9 mi
    22h 27m
    $214–309

  5. Fly to Philadelphia International Airport, train

    1. Fly from Key West International Airport (EYW) to Philadelphia International Airport (PHL)plane plane EYW - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    10h 11m
    $260–760

Florida Keys to Mechanicsburg by foot and bus

Calendar4Weekly Services
Duration32h 12mAverage Duration
Ticket$216Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florida Keys to Mechanicsburg.ExpandLaunch map view
  • Distance: 1,173.6 mi
  • Duration: 9h 24m

What companies run services between Florida Keys, FL, USA and Mechanicsburg, Cumberland County, PA, USA?

United Airlines, American Airlines, and two other airlines fly from Key West International Airport (EYW) to Harrisburg International Airport (MDT) 5 times a day. Alternatively, you can take a vehicle from Florida Keys to E Main St & Arch St WB via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Washington Union Station, Harrisburg Bus Station, and Market Square Transfer Center in around 32h 12m.

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Need to know: Greyhound

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