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How to get fromFlorida Keys to North Carolinaby plane, shuttle, bus, train, car, or bus (Greyhound, Flixbus)

Find Transport to North Carolina

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There are 10 ways to get from Florida Keys to North Carolina by plane, shuttle, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Key West International Airport to Charlotte Douglas International Airport

    best
    1. Fly from Key West International Airport (EYW) to Charlotte Douglas International Airport (CLT)plane plane EYW - CLT
    5h 36m
    $205–767

  2. Drive  867.4 mi

    cheapest
    1. Drive from Florida Keys to Charlottecar car 867.4 mi
    15h 3m
    $159–229

  3. Shuttle, bus

    1. Take a shuttle bus from Summerland Key - Mote Marine Lab to Fort Lauderdale, FL - International Airportshuttle bus
    2. Take the bus from Fort Lauderdale International Airport to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Charlotte Bus Stationbus bus
    25h 25m
    $307–409

  4. Bus, train via Fayetteville

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Amtrak Station to Fayetteville Amtrak Stationtrain train
    3. Take the bus from Fayetteville Bus Station to Charlotte Bus Stationbus bus
    27h 24m
    $525–847

  5. Fly Key West International Airport to Raleigh-Durham International Airport

    1. Fly from Key West International Airport (EYW) to Raleigh-Durham International Airport (RDU)plane plane EYW - RDU
    6h 24m
    $205–717

  6. Shuttle to Miami International Airport, fly to Wilmington International Airport

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Wilmington International Airport (ILM)plane plane MIA - ILM
    7h 44m
    $236–611

  7. Shuttle to Miami International Airport, fly to Charlotte Douglas International Airport

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Charlotte Douglas International Airport (CLT)plane plane MIA - CLT
    8h 16m
    $285–887

  8. Shuttle to Miami International Airport, fly to Piedmont Triad International Airport

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Piedmont Triad International Airport (GSO)plane plane MIA - GSO
    8h 5m
    $245–569

  9. Bus

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Charlotte Bus Stationbus bus
    25h 53m
    $167–254

  10. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Amtrak Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    31h 54m
    $635–1,055

Florida Keys to North Carolina by foot, bus, and shuttle

Calendar7Weekly Services
Duration25h 25mAverage Duration
Ticket$307Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florida Keys to North Carolina.ExpandLaunch map view
  • Distance: 781.8 mi
  • Duration: 5h 36m

What companies run services between Florida Keys, FL, USA and North Carolina, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to Charlotte Douglas International Airport (CLT) every 4 hours. Alternatively, you can take a vehicle from Florida Keys to Charlotte Bus Station via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Fayetteville Bus Station in around 25h 53m.

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