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How to get fromFlorida Keys to Panama City Beachby plane, shuttle, bus, car, bus (Greyhound, Flixbus), or train

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There are 9 ways to get from Florida Keys to Panama City Beach by plane, shuttle, bus, car, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Key West International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP)plane plane EYW - ECP
    7h 6m
    $222–569

  2. Bus via Fort Lauderdale

    cheapest
    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Ft Lauderdale Broward Park & Ridebus bus
    3. Take the bus from Ft Lauderdale Broward Park & Ride to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    19h 56m
    $124–225

  3. Shuttle, bus

    1. Take a shuttle bus from Summerland Key - Mote Marine Lab to Miami, FL - International Airportshuttle bus
    2. Take the bus from Miami Airport to Tallahassee - FSU - Old St Augustine at Intramural Fieldbus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    18h 54m
    $298–458

  4. Drive 691.8 mi

    1. Drive from Florida Keys to Panama City Beachcar car 691.8 mi
    13h 39m
    $127–183

  5. Fly Key West International Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Key West International Airport (EYW) to Destin–Fort Walton Beach Airport (VPS)plane plane EYW - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    8h 27m
    $167–470

  6. Shuttle to Miami International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS)plane plane MIA - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    8h 47m
    $217–520

  7. Fly Key West International Airport to Tallahassee, bus

    1. Fly from Key West International Airport (EYW) to Tallahassee (TLH)plane plane EYW - TLH
    2. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    9h 30m
    $209–574

  8. Bus

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    23h 12m
    $130–256

  9. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    23h 17m
    $219–442

Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar38Weekly Planes
Duration5h 34mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Florida Keys to Panama City Beach.ExpandLaunch map view
  • Distance: 525.6 mi
  • Duration: 7h 6m

What companies run services between Florida Keys, FL, USA and Panama City Beach, FL, USA?

Delta and American Airlines fly from Key West International Airport (EYW) to Northwest Florida Beaches International Airport (ECP) 5 times a day. Alternatively, you can take a vehicle from Florida Keys to Panama City Beach via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Ft Lauderdale Broward Park & Ride, Tallahassee, and Panama City Beach Bus Station in around 19h 56m.

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