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How to get fromFlorida Keys to Port Saint Lucieby bus (Greyhound), car, plane, bus, shuttle, or train

Find Transport to Port Saint Lucie

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There are 8 ways to get from Florida Keys to Port Saint Lucie by bus (Greyhound), car, plane, bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport to Fort Piercebus bus Miami–Tallahassee via Orlando
    8h 19m
    $52–84

  2. Drive 256.9 mi

    cheapest
    1. Drive from Florida Keys to Port Saint Luciecar car 256.9 mi
    5h 1m
    $47–68

  3. Fly Key West International Airport to Orlando, bus

    1. Fly from Key West International Airport (EYW) to Orlando (MCO)plane plane EYW - MCO
    2. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    7h 7m
    $187–821

  4. Shuttle, bus

    1. Take a shuttle bus from Summerland Key - Mote Marine Lab to Fort Lauderdale, FL - International Airportshuttle bus To the Airports
    2. Take the bus from Fort Lauderdale Airport to Fort Piercebus bus Miami–Tallahassee via Orlando
    7h 57m
    $196–249

  5. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    9h 2m
    $55–90

  6. Fly Key West International Airport to Miami International Airport, train, bus

    1. Fly from Key West International Airport (EYW) to Miami International Airport (MIA)plane plane EYW - MIA
    2. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    7h 35m
    $155–390

  7. Fly Key West International Airport to Orlando Sanford, drive

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar car
    6h 20m
    $156–419

  8. Shuttle to Miami International Airport, fly to Orlando, bus

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Orlando (MCO)plane plane MIA - MCO
    3. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    9h 53m
    $782–1,341

Florida Keys to Port Saint Lucie by foot, bus, and tram

Calendar31Weekly Services
Duration8h 19mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Florida Keys to Port Saint Lucie.ExpandLaunch map view
  • Distance: 267.1 mi
  • Duration: 8h 19m

What companies run services between Florida Keys, FL, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Florida Keys to Fort Pierce via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami, Airport Intermodal Station, Miami Airport Station, Miami International Airport, and Miami Airport in around 8h 19m.

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