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How to get fromFlorida Keys to San Diegoby plane, bus, train, car, or shuttle

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There are 5 ways to get from Florida Keys to San Diego by plane, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Key West International Airport

    best
    1. Fly from Key West International Airport (EYW) to San Diego International Airport (SAN)plane plane EYW - SAN
    10h 8m
    $272–864

  2. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    4. Take the train from Fullerton Amtrak Station to San Diegotrain train
    4d 3h
    $1,420–3,037

  3. Drive 2,758.1 mi

    1. Drive from Florida Keys to San Diegocar car 2,758.1 mi
    45h 30m
    $504–728

  4. Shuttle to Miami International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to San Diego International Airport (SAN)plane plane MIA - SAN
    10h 50m
    $332–644

  5. Shuttle to Fort Lauderdale–Hollywood International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to San Diego International Airport (SAN)plane plane FLL - SAN
    11h 37m
    $492–1,304

Florida Keys to San Diego by foot, bus, taxi, and train

Calendar7Weekly Services
Duration4d 3hAverage Duration
Ticket$1,420Cheapest Price
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Questions & Answers

Map of how to get from Florida Keys to San Diego.ExpandLaunch map view
  • Distance: 2,246.6 mi
  • Duration: 10h 8m

What companies run services between Florida Keys, FL, USA and San Diego, CA, USA?

American Airlines and Delta fly from Key West International Airport (EYW) to San Diego International Airport (SAN) 5 times a day.

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