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How to get fromFlorida Keys to San Diegoby plane, bus, train, car, or shuttle

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There are 5 ways to get from Florida Keys to San Diego by plane, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Key West International Airport

    best
    1. Fly from Key West International Airport (EYW) to San Diego International Airport (SAN)plane plane EYW - SAN
    10h 9m
    $242–764

  2. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train
    4. Take the train from Fullerton Amtrak Station to San Diegotrain train
    4d 3h
    $2,398–3,852

  3. Drive  2,767.8 mi

    1. Drive from Florida Keys to San Diegocar car 2,767.8 mi
    45h 6m
    $490–707

  4. Shuttle to Miami International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to San Diego International Airport (SAN)plane plane MIA - SAN
    10h 59m
    $272–644

  5. Shuttle to Fort Lauderdale–Hollywood International Airport, fly

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to San Diego International Airport (SAN)plane plane FLL - SAN
    11h 37m
    $492–1,204

Florida Keys to San Diego by foot, bus, taxi, and train

Calendar7Weekly Services
Duration4d 3hAverage Duration
Ticket$2,398Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florida Keys to San Diego.ExpandLaunch map view
  • Distance: 2,246.6 mi
  • Duration: 10h 9m

What companies run services between Florida Keys, FL, USA and San Diego, CA, USA?

United Airlines, Delta, and American Airlines fly from Key West International Airport (EYW) to San Diego International Airport (SAN) 5 times a day.

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