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How to get fromFlorida Keys to Sanfordby plane, train, bus, bus (Greyhound, Flixbus), car, or shuttle

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There are 10 ways to get from Florida Keys to Sanford by plane, train, bus, bus (Greyhound, Flixbus), car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Key West International Airport to Orlando, train

    best
    1. Fly from Key West International Airport (EYW) to Orlando (MCO)plane plane EYW - MCO
    2. Take the train from Sand Lake Road to Sanfordtrain train
    6h 3m
    $167–771

  2. Bus

    cheapest
    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the bus from Miami Airport Station to Orlandobus bus FlixBus 2411 / ...
    12h 59m
    $60–110

  3. Bus, train

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami to Orlandotrain train
    3. Take the train from Sand Lake Road to Sanfordtrain train
    12h 3m
    $88–248

  4. Drive 373.2 mi

    1. Drive from Florida Keys to Sanfordcar car 373.2 mi
    7h 48m
    $69–99

  5. Fly Key West International Airport to Orlando Sanford

    1. Fly from Key West International Airport (EYW) to Orlando Sanford (SFB)plane plane EYW - SFB
    3h 49m
    $137–404

  6. Shuttle to Miami International Airport, fly to Orlando, train

    1. Take a shuttle bus from Big Pine Key, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Orlando (MCO)plane plane MIA - MCO
    3. Take the train from Sand Lake Road to Sanfordtrain train
    8h 49m
    $707–1,291

  7. Shuttle to Fort Lauderdale–Hollywood International Airport, fly to Orlando, train

    1. Take a shuttle bus from Big Pine Key, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Orlando (MCO)plane plane FLL - MCO
    3. Take the train from Sand Lake Road to Sanfordtrain train
    9h 19m
    $427–811

  8. Bus, train via West Palm Beach

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus
    2. Take the train from Miami Airport Station to West Palm Beach Stationtrain train
    3. Take the bus from West Palm Beach, FL to Orlando - RedCoach Station, FLbus bus
    4. Take the train from Sand Lake Road to Sanfordtrain train
    13h 7m
    $71–142

  9. Bus, train via Pembroke Pines

    1. Take the bus from Big Pine Key to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the train from Hollywood Amtrak Station to Winter Park Amtrak Stationtrain train Silver Meteor / ...
    13h 47m
    $106–224

  10. Shuttle, bus

    1. Take a shuttle bus from Summerland Key - Mote Marine Lab to Miami, FL - International Airportshuttle bus To the Airports
    2. Take the bus from Miami International Airport to Orlandobus bus Miami to Orlando
    13h 56m
    $191–240

Florida Keys to Sanford by foot, bus, and train

Calendar38Weekly Services
Duration12h 59mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from Florida Keys to Sanford.ExpandLaunch map view
  • Distance: 339.3 mi
  • Duration: 6h 3m

What companies run services between Florida Keys, FL, USA and Sanford, FL, USA?

You can take a vehicle from Florida Keys to Sanford via Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, Orlando, Florida Mall, N Garland Ave & W Amelia St, New York Ave & Welbourne Ave, and Winter Park in around 12h 59m. Alternatively, Allegiant Air flies from Key West International Airport (EYW) to Orlando Sanford (SFB) twice a week.

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