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How to get fromFlorida Panhandle to Key Westby car, plane, bus, ferry, or train

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There are 9 ways to get from Florida Panhandle to Key West by car, plane, bus, ferry, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Tallahassee, fly

    best
    1. Drive from Florida Panhandle to Tallahassee (TLH)car car
    2. Fly from Tallahassee (TLH) to Key West International Airport (EYW)plane plane TLH - EYW
    4h 47m
    $71–328

  2. Drive, bus, ferry

    1. Drive from Florida Panhandle to Tallahasseecar car
    2. Take the bus from Tallahassee to Fort Myersbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    14h 38m
    $271–316

  3. Drive 659.7 mi

    1. Drive from Florida Panhandle to Key Westcar car 659.7 mi
    13h 9m
    $121–174

  4. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Florida Panhandle to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    5h 57m
    $91–378

  5. Drive to Destin–Fort Walton Beach Airport, fly

    1. Drive from Florida Panhandle to Destin–Fort Walton Beach Airport (VPS)car car
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    6h 27m
    $85–340

  6. Drive to Dothan Regional Airport, fly

    1. Drive from Florida Panhandle to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Key West International Airport (EYW)plane plane DHN - EYW
    6h 39m
    $91–374

  7. Drive, bus

    1. Drive from Florida Panhandle to Tallahassee - FSU - Old St Augustine at Intramural Fieldcar car
    2. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to Miami Airportbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    17h 41m
    $151–289

  8. Drive, bus, train

    1. Drive from Florida Panhandle to Tallahassee - FSU - Old St Augustine at Intramural Fieldcar car
    2. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to Orlando - RedCoach Station, FLbus bus
    3. Take the train from Orlando to Miamitrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    18h 12m
    $157–384

  9. Drive, bus, ferry via University

    1. Drive from Florida Panhandle to Tallahassee - FSU - Old St Augustine at Intramural Fieldcar car
    2. Take the bus from Tallahassee - FSU - Old St Augustine at Intramural Field to University of South Florida - 3801 USF Holly Drbus bus
    3. Take the bus from University of South Florida to Fort Myers Bus Stopbus bus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    18h 38m
    $228–319

Tallahassee (TLH) to Key West International Airport (EYW) flights

Calendar42Weekly Planes
Duration5h 8mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Florida Panhandle to Key West.ExpandLaunch map view
  • Distance: 491.9 mi
  • Duration: 4h 47m

What companies run services between Florida Panhandle, FL, USA and Key West, FL, USA?

There is no direct connection from Florida Panhandle to Key West. However, you can drive to Tallahassee (TLH) airport, fly to Key West International Airport (EYW), then take the taxi to Key West. Alternatively, you can take a vehicle from Florida Panhandle to Key West, FL via Tallahassee, Fort Myers, and Fort Myers Beach, FL in around 14h 38m.

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