Rome2Rio

How to get fromFlorida to Florenceby train (Amtrak), bus (Flixbus), car, plane, bus, or train

Find Transport to Florence

See all options
QR code to download the Rome2Rio app

Download the Rome2Rio travel app

Scan QR code with your phone to download the app

Download on the App StoreGet it on Google Play

There are 8 ways to get from Florida to Florence by train (Amtrak), bus (Flixbus), car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Jacksonville to Florence Stationtrain train Silver Meteor
    6h 20m
    $194–306
  2. Drive  307 mi

    cheapest
    1. Drive from Jacksonville to Florencecar car 307 mi
    5h 2m
    $53–76
  3. Bus (Flixbus)

    1. Take the bus from Jacksonville to Florencebus bus FlixBus N2472
    6h 54m
    $67–96
  4. Fly Orlando to Myrtle Beach, bus

    1. Fly from Orlando (MCO) to Myrtle Beach (MYR)plane plane MCO - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h
    $135–245
  5. Fly Tampa to Myrtle Beach, bus

    1. Fly from Tampa (TPA) to Myrtle Beach (MYR)plane plane TPA - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 5m
    $115–375
  6. Fly Fort Lauderdale–Hollywood International Airport to Myrtle Beach, bus

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Myrtle Beach (MYR)plane plane FLL - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 10m
    $95–416
  7. Fly Tallahassee to Charlotte Douglas International Airport, bus

    1. Fly from Tallahassee (TLH) to Charlotte Douglas International Airport (CLT)plane plane TLH - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    7h 18m
    $130–618
  8. Fly Tampa to Charleston International Airport, train

    1. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    7h 56m
    $136–536

Orlando (MCO) to Myrtle Beach (MYR) flights

Calendar31Weekly Planes
Duration3h 2mAverage Duration
Ticket$53Cheapest Price
See schedules

Comparing Your Travel Options

What companies run services between Florida, USA and Florence, SC, USA?

Amtrak operates a train from Jacksonville to Florence Station once daily. Tickets cost $180–290 and the journey takes 6h 11m. Alternatively, Flixbus USA operates a bus from Jacksonville to Florence 5 times a week. Tickets cost $50–75 and the journey takes 5h 35m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There