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How to get fromFlorida to Florenceby bus (Flixbus), train (Amtrak), car, plane, bus, bus (Greyhound), or train

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There are 10 ways to get from Florida to Florence by bus (Flixbus), train (Amtrak), car, plane, bus, bus (Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Flixbus)

    best
    1. Take the bus from Jacksonville to Florencebus bus FlixBus N2472
    6h 54m
    $62–96

  2. Drive  307 mi

    cheapest
    1. Drive from Jacksonville to Florencecar car 307 mi
    5h 2m
    $56–81

  3. Train (Amtrak)

    1. Take the train from Jacksonville to Florence Stationtrain train Silver Meteor
    7h 38m
    $192–303

  4. Fly Orlando to Myrtle Beach, bus

    1. Fly from Orlando (MCO) to Myrtle Beach (MYR)plane plane MCO - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h
    $124–244

  5. Bus via Camden (Greyhound)

    1. Take the bus from Jacksonville to Camdenbus bus Greyhound US0644S
    2. Take the bus from Camden to Florence Bus Stationbus bus Greyhound US0641S / ...
    10h 13m
    $65–106

  6. Fly Tampa to Myrtle Beach, bus

    1. Fly from Tampa (TPA) to Myrtle Beach (MYR)plane plane TPA - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 5m
    $114–374

  7. Fly Fort Lauderdale–Hollywood International Airport to Myrtle Beach, bus

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Myrtle Beach (MYR)plane plane FLL - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    6h 10m
    $184–445

  8. Fly Tallahassee to Charlotte Douglas International Airport, bus

    1. Fly from Tallahassee (TLH) to Charlotte Douglas International Airport (CLT)plane plane TLH - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    7h 17m
    $124–558

  9. Fly Tampa to Charleston International Airport, train

    1. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    2. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    7h 56m
    $136–551

  10. Fly Jacksonville to Charlotte Douglas International Airport, bus

    1. Fly from Jacksonville (JAX) to Charlotte Douglas International Airport (CLT)plane plane JAX - CLT
    2. Take the bus from Charlotte Bus Station to Camdenbus bus
    3. Take the bus from Camden to Florence Bus Stationbus bus
    8h 38m
    $97–493

Florida to Florence by bus and train (Amtrak)

Calendar7Weekly Services
Duration7h 38mAverage Duration
Ticket$192Cheapest Price
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Comparing Your Travel Options

Map of how to get from Florida to Florence.ExpandLaunch map view
  • Distance: 320.6 mi
  • Duration: 6h 54m

What companies run services between Florida, USA and Florence, SC, USA?

Flixbus USA operates a bus from Jacksonville to Florence 5 times a week. Tickets cost $45–75 and the journey takes 5h 35m. Alternatively, Amtrak operates a train from Jacksonville to Florence Station once daily. Tickets cost $190–300 and the journey takes 6h 11m.

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Bus operators

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