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How to get fromFlorida to Knoxvilleby plane, train, bus, bus (Flixbus), car, or taxi

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There are 10 ways to get from Florida to Knoxville by plane, train, bus, bus (Flixbus), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Orlando Sanford

    best
    1. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    2h 29m
    $226–793

  2. Drive 507.6 mi

    cheapest
    1. Drive from Jacksonville to Knoxvillecar car 507.6 mi
    9h 39m
    $93–134

  3. Train, bus via Farragut

    1. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York to Knoxvillebus bus Nyc
    33h 36m
    $505–906

  4. Bus

    1. Take the bus from Jacksonville to New York City Chinatownbus bus FlixBus N2472
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 48m
    $261–378

  5. Fly from Orlando

    1. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3h 36m
    $157–672

  6. Fly from Fort Lauderdale–Hollywood International Airport

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    3h 51m
    $187–773

  7. Fly from Miami International Airport

    1. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    3h 47m
    $188–723

  8. Taxi to Punta Gorda Airport, fly

    1. Take the taxi from Cape Coral to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Mcghee Tyson Airport (TYS)plane plane PGD - TYS
    2h 48m
    $267–878

  9. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Mcghee Tyson Airport (TYS)plane plane PIE - TYS
    4h 19m
    $180–725

  10. Train, bus

    1. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    33h 40m
    $460–816

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar10Weekly Planes
Duration1h 38mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from Florida to Knoxville.ExpandLaunch map view
  • Distance: 545.7 mi
  • Duration: 2h 29m

What companies run services between Florida, USA and Knoxville, TN, USA?

Allegiant Air flies from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) once daily. Alternatively, you can take a bus from Newnan St + Ashley St to Knoxville Station Hall of Fame via JRTC Bay J, Jacksonville, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 36h 48m.

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