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How to get fromFlorida to Knoxvilleby plane, bus, shuttle, car, train, or taxi

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There are 10 ways to get from Florida to Knoxville by plane, bus, shuttle, car, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Orlando Sanford

    best
    1. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    2h 29m
    $246–943

  2. Drive  507.6 mi

    cheapest
    1. Drive from Jacksonville to Knoxvillecar car 507.6 mi
    9h 39m
    $93–134

  3. Bus, shuttle, drive

    1. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte to Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    17h 47m
    $309–364

  4. Train, bus, taxi, shuttle, drive

    1. Take the train from Jacksonville to Carytrain train
    2. Take the train from Cary to High Pointtrain train
    3. Take the bus from Forsyth Hospital to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    23h 21m
    $418–661

  5. Fly from Orlando

    1. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    3h 39m
    $187–872

  6. Taxi to Punta Gorda Airport, fly

    1. Take the taxi from Cape Coral to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Mcghee Tyson Airport (TYS)plane plane PGD - TYS
    2h 44m
    $279–1,019

  7. Fly from Fort Lauderdale–Hollywood International Airport

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    3h 51m
    $227–1,023

  8. Fly from Miami International Airport

    1. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    3h 54m
    $208–923

  9. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Mcghee Tyson Airport (TYS)plane plane PIE - TYS
    4h 15m
    $190–875

  10. Bus, taxi, shuttle, drive

    1. Take the bus from Jacksonville to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    20h 36m
    $351–439

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar15Weekly Planes
Duration1h 37mAverage Duration
Ticket$133Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Florida to Knoxville.ExpandLaunch map view
  • Distance: 545.7 mi
  • Duration: 2h 29m

What companies run services between Florida, USA and Knoxville, TN, USA?

Allegiant Air flies from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) twice daily.

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