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How to get fromFlorida to Santeeby bus (Flixbus, Greyhound), train, taxi, car, or plane

Find Transport to Santee

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There are 8 ways to get from Florida to Santee by bus (Flixbus, Greyhound), train, taxi, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Jacksonville to Orangeburgbus bus FlixBus 2433
    4h 53m
    $117–162

  2. Drive  240.4 mi

    cheapest
    1. Drive from Jacksonville to Santeecar car 240.4 mi
    3h 56m
    $44–64

  3. Train, taxi (Amtrak)

    1. Take the train from Jacksonville to Denmark Amtrak Stationtrain train Floridian
    2. Take the taxi from Denmark Amtrak Station to Santeetaxi taxi
    6h 50m
    $262–383

  4. Fly from Orlando, drive

    1. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 10m
    $92–298

  5. Fly from Tampa, drive

    1. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 15m
    $92–478

  6. Fly from Miami International Airport, drive

    1. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 10m
    $503–1,019

  7. Fly from Fort Lauderdale–Hollywood International Airport, drive

    1. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 16m
    $412–1,119

  8. Fly from Ft. Myers, drive

    1. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    5h 29m
    $114–621

Orlando (MCO) to Charleston International Airport (CHS) flights

Calendar21Weekly Planes
Duration2h 24mAverage Duration
Ticket$81Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Florida to Santee.ExpandLaunch map view
  • Distance: 269.9 mi
  • Duration: 4h 53m

What companies run services between Florida, USA and Santee, SC, USA?

Flixbus USA operates a bus from Jacksonville to Orangeburg once daily. Tickets cost $35–55 and the journey takes 4h 25m. Greyhound USA also services this route once daily.

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