Rome2Rio

How to get fromFort Myers to Charlestonby bus, plane, train, or car

Find Transport to Charleston

See all options

There are 8 ways to get from Fort Myers to Charleston by bus, plane, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 140 bus to Ft. Myers, fly

    best
    1. Take the bus from Edison Mall Transfer Ctr to South Fort Myers Transfer/P&Rbus bus
    2. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    6h 5m
    $106–507

  2. Drive 529.3 mi

    cheapest
    1. Drive from Fort Myers to Charlestoncar car 529.3 mi
    9h 35m
    $97–140

  3. Bus, train (Amtrak)

    1. Take the bus from Fort Myers Amtrak Bus Stop to Orlandobus bus Amtrak Thruway Connecting Service
    2. Take the train from Orlando to Charleston Amtrak Stationtrain train Silver Meteor
    16h 38m
    $212–395

  4. Bus to Fort Lauderdale–Hollywood International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    6h 35m
    $193–1,137

  5. Bus to Miami International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    7h 32m
    $527–1,044

  6. Bus to Tampa, fly

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    8h 31m
    $166–381

  7. Bus to Orlando, fly

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    10h 33m
    $105–314

  8. Bus, Amtrak Thruway, train

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Take the bus from Sarasota Amtrak Bus Stop to Orlando, FLbus bus
    3. Take the train from Orlando to Charleston Amtrak Stationtrain train
    18h 26m
    $187–359

Fort Myers to Charleston by bus and train

Calendar7Weekly Services
Duration18h 26mAverage Duration
Ticket$187Cheapest Price
See schedules

Questions & Answers

Map of how to get from Fort Myers to Charleston.ExpandLaunch map view
  • Distance: 480.5 mi
  • Duration: 6h 5m

What companies run services between Fort Myers, FL, USA and Charleston, SC, USA?

There is no direct connection from Fort Myers to Charleston. However, you can take the line 140 bus to South Fort Myers Transfer/P&R, take the line 50 bus to Rsw, walk to Ft. Myers (RSW) airport, fly to Charleston International Airport (CHS), walk to Charleston International Airport, then take the line 11 bus to Transit Mall. Alternatively, you can take a vehicle from Fort Myers to Transit Mall via Fort Myers Amtrak Bus Stop, Orlando, Orlando, Charleston Amtrak Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 16h 38m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides