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How to get fromFort Myers to Columbiaby plane, bus, train, bus (Flixbus, Greyhound), or car

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There are 4 ways to get from Fort Myers to Columbia by plane, bus, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Ft. Myers (RSW) to Columbia (CAE)plane plane RSW - CAE
    8h 1m
    $226–1,207

  2. Bus

    cheapest
    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Sumter Bus Stopbus bus
    4. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Senate Northbus bus 44
    18h 56m
    $104–189

  3. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus FlixBus 2421
    2. Take the train from Tampa to Columbia Stationtrain train Floridian
    16h
    $186–390

  4. Drive 579.6 mi

    1. Drive from Fort Myers to Columbiacar car 579.6 mi
    10h 9m
    $106–153

Fort Myers to Columbia by bus and train

Calendar7Weekly Services
Duration16hAverage Duration
Ticket$186Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Columbia.ExpandLaunch map view
  • Distance: 538 mi
  • Duration: 8h 1m

What companies run services between Fort Myers, FL, USA and Columbia, SC, USA?

Delta, American Airlines, and United Airlines fly from Ft. Myers (RSW) to Columbia (CAE) hourly. Alternatively, you can take a bus from Fort Myers Bus Stop to Assembly Senate North via Orlando Bus Station, Jacksonville, Sumter Bus Stop, and James E Clyburn Intermodal Transportation Center in around 18h 56m.

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