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How to get fromFort Myers to Des Moinesby plane, bus (Flixbus, Greyhound), bus, train, car, or taxi

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There are 7 ways to get from Fort Myers to Des Moines by plane, bus (Flixbus, Greyhound), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Ft. Myers

    best
    1. Fly from Ft. Myers (RSW) to Des Moines (DSM)plane plane RSW - DSM
    6h 22m
    $240–1,026

  2. Drive to Orlando Sanford, fly

    cheapest
    1. Drive from Fort Myers to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    6h 55m
    $219–867

  3. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Des Moinesbus bus
    33h 20m
    $245–463

  4. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the train from Tampa to Chicago Union Stationtrain train
    3. Take the bus from Chicago to Des Moinesbus bus
    2d 5h
    $654–1,357

  5. Drive 1,436.5 mi

    1. Drive from Fort Myers to Des Moinescar car 1,436.5 mi
    25h 29m
    $263–379

  6. Bus to Sarasota–Bradenton International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Des Moines (DSM)plane plane SRQ - DSM
    6h 54m
    $250–1,143

  7. Taxi to Punta Gorda Airport, fly

    1. Take the taxi from Fort Myers to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Des Moines (DSM)plane plane PGD - DSM
    3h 53m
    $278–916

Fort Myers to Des Moines by bus

Calendar7Weekly Buses
Duration33h 20mAverage Duration
Ticket$245Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Des Moines.ExpandLaunch map view
  • Distance: 1,259.3 mi
  • Duration: 6h 22m

What companies run services between Fort Myers, FL, USA and Des Moines, IA, USA?

Allegiant Air, Delta, and three other airlines fly from Ft. Myers (RSW) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Fort Myers Bus Stop to Des Moines via Tampa Bus Station, Atlanta Bus Station, and St Louis Bus Station in around 33h 20m.

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