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How to get fromFort Myers to Des Moinesby plane, bus (Flixbus, Greyhound), bus, train, car, or taxi

Find Transport to Des Moines

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There are 7 ways to get from Fort Myers to Des Moines by plane, bus (Flixbus, Greyhound), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Ft. Myers

    best
    1. Fly from Ft. Myers (RSW) to Des Moines (DSM)plane plane RSW - DSM
    6h 22m
    $142–628

  2. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    36h 25m
    $236–401

  3. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the train from Tampa to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    2d 5h
    $515–1,220

  4. Drive  1,436.5 mi

    1. Drive from Fort Myers to Des Moinescar car 1,436.5 mi
    25h 28m
    $263–379

  5. Bus to Sarasota–Bradenton International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Des Moines (DSM)plane plane SRQ - DSM
    6h 52m
    $180–793

  6. Taxi to Punta Gorda Airport, fly

    1. Take the taxi from Fort Myers to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Des Moines (DSM)plane plane PGD - DSM
    3h 48m
    $191–610

  7. Drive to Orlando Sanford, fly

    1. Drive from Fort Myers to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    6h 46m
    $145–549

Fort Myers to Des Moines by bus

Calendar5Weekly Buses
Duration36h 25mAverage Duration
Ticket$236Cheapest Price
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Comparing Your Travel Options

Map of how to get from Fort Myers to Des Moines.ExpandLaunch map view
  • Distance: 1,259.3 mi
  • Duration: 6h 22m

What companies run services between Fort Myers, FL, USA and Des Moines, IA, USA?

Allegiant Air, Delta, and three other airlines fly from Ft. Myers (RSW) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Fort Myers Bus Stop to Des Moines via Tampa Bus Station, Atlanta Bus Station, and Indianapolis Union Station in around 36h 25m.

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