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How to get fromFort Myers to Florida Keysby car, bus, or plane

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There are 5 ways to get from Fort Myers to Florida Keys by car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 273.8 mi

    best
    1. Drive from Fort Myers to Key Westcar car 273.8 mi
    5h 49m
    $50–73

  2. Bus to Miami International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Key West International Airport (EYW)plane plane MIA - EYW
    5h 11m
    $52–250

  3. Bus to Tampa, fly

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    6h 43m
    $98–428

  4. Bus to Orlando, fly

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    8h 46m
    $108–710

  5. Bus to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    7h 55m
    $57–281

Miami International Airport (MIA) to Key West International Airport (EYW) flights

Calendar27Weekly Planes
Duration1h 4mAverage Duration
Ticket$26Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Florida Keys.ExpandLaunch map view
  • Distance: 273.8 mi
  • Duration: 5h 49m

What companies run services between Fort Myers, FL, USA and Florida Keys, Monroe County, FL, USA?

You can drive from Fort Myers to Key West in around 5h 49m.

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