Rome2Rio

How to get fromFort Myers to Florida Panhandleby bus, car, or plane

Find Transport to Florida Panhandle

See all options

There are 9 ways to get from Fort Myers to Florida Panhandle by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Fort Myers to Tallahassee FSUbus bus Miami–Tallahassee via Tampa
    2. Drive from Tallahassee FSU to Florida Panhandlecar car
    9h 8m
    $128–226

  2. Bus, drive via Tampa

    cheapest
    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Tallahasseebus bus
    3. Drive from Capital Circle NW and Commonwealth Boulevard to Florida Panhandlecar car
    11h 18m
    $67–125

  3. Drive 415.7 mi

    1. Drive from Fort Myers to Florida Panhandlecar car 415.7 mi
    7h 59m
    $76–110

  4. Fly Ft. Myers to Tallahassee, drive

    1. Fly from Ft. Myers (RSW) to Tallahassee (TLH)plane plane RSW - TLH
    2. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    8h 14m
    $124–620

  5. Bus, drive via University

    1. Take the bus from Fort Myers Bus Stop to University of South Floridabus bus
    2. Take the bus from Tampa USF to Tallahassee FSUbus bus
    3. Drive from Tallahassee FSU to Florida Panhandlecar car
    10h 54m
    $97–181

  6. Fly Ft. Myers to Northwest Florida Beaches International Airport, drive

    1. Fly from Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP)plane plane RSW - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Florida Panhandlecar car
    8h 20m
    $108–490

  7. Bus, bus to Miami International Airport, fly to Tallahassee, drive

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Take the bus from Fort Lauderdale Airport to Miami Airportbus bus
    3. Fly from Miami International Airport (MIA) to Tallahassee (TLH)plane plane MIA - TLH
    4. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    7h 2m
    $98–423

  8. Fly Ft. Myers to Dothan Regional Airport, drive

    1. Fly from Ft. Myers (RSW) to Dothan Regional Airport (DHN)plane plane RSW - DHN
    2. Drive from Dothan Regional Airport (DHN) to Florida Panhandlecar car
    8h 35m
    $108–487

  9. Bus to Fort Lauderdale–Hollywood International Airport, fly to Tallahassee, drive

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Tallahassee (TLH)plane plane FLL - TLH
    3. Drive from Tallahassee (TLH) to Florida Panhandlecar car
    6h 8m
    $242–900

Ft. Myers (RSW) to Tallahassee (TLH) flights

Calendar83Weekly Planes
Duration5h 47mAverage Duration
Ticket$115Cheapest Price
See schedules

Questions & Answers

Map of how to get from Fort Myers to Florida Panhandle.ExpandLaunch map view
  • Distance: 463.9 mi
  • Duration: 9h 8m

What companies run services between Fort Myers, FL, USA and Florida Panhandle, FL, USA?

There is no direct connection from Fort Myers to Florida Panhandle. However, you can take the taxi to Fort Myers, take the bus to Tallahassee FSU, then drive to Florida Panhandle. Alternatively, you can drive from Fort Myers to Florida Panhandle in around 7h 59m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound