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How to get fromFort Myers to Knoxvilleby plane, bus (Flixbus), bus, train, car, or taxi

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There are 10 ways to get from Fort Myers to Knoxville by plane, bus (Flixbus), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Mcghee Tyson Airport

    best
    1. Fly from Ft. Myers (RSW) to Mcghee Tyson Airport (TYS)plane plane RSW - TYS
    7h 13m
    $208–875

  2. Drive 752.7 mi

    cheapest
    1. Drive from Fort Myers to Knoxvillecar car 752.7 mi
    13h 19m
    $138–199

  3. Bus via Baltimore

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Baltimore Downtown Bus Stationbus bus
    3. Take the bus from Baltimore Downtown Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    42h 6m
    $394–627

  4. Bus, train via Oak Ridge

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    44h 12m
    $592–1,067

  5. Taxi to Punta Gorda Airport, fly to Mcghee Tyson Airport

    1. Take the taxi from Fort Myers to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Mcghee Tyson Airport (TYS)plane plane PGD - TYS
    2h 41m
    $256–815

  6. Bus to Sarasota–Bradenton International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Mcghee Tyson Airport (TYS)plane plane SRQ - TYS
    6h
    $218–943

  7. Taxi to Punta Gorda Airport, fly to Asheville Regional Airport, drive

    1. Take the taxi from Fort Myers to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Asheville Regional Airport (AVL)plane plane PGD - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    4h 34m
    $168–490

  8. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    5h 41m
    $207–806

  9. Bus

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 40m
    $315–494

  10. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Hollywood Sheridan Trirail Stationbus bus
    2. Take the train from Fort Lauderdale Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    45h 15m
    $603–1,106

Ft. Myers (RSW) to Mcghee Tyson Airport (TYS) flights

Calendar90Weekly Planes
Duration5h 14mAverage Duration
Ticket$154Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Knoxville.ExpandLaunch map view
  • Distance: 682.4 mi
  • Duration: 7h 13m

What companies run services between Fort Myers, FL, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Ft. Myers (RSW) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Fort Myers Bus Stop to Knoxville via Orlando Bus Station, Baltimore Downtown Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 42h 6m.

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