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How to get fromFort Myers to Lake Cityby bus (Flixbus, Greyhound), car, bus, or plane

Find Transport to Lake City

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There are 5 ways to get from Fort Myers to Lake City by bus (Flixbus, Greyhound), car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Fort Myers 7-11 to University of South Florida - 3801 USF Holly Drbus bus
    2. Take the bus from University of South Florida to Gainesvillebus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    8h 59m
    $75–135

  2. Drive 270.5 mi

    cheapest
    1. Drive from Fort Myers to Lake Citycar car 270.5 mi
    5h 8m
    $50–72

  3. Bus, fly

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Jacksonville (JAX)plane plane FLL - JAX
    3. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    8h 11m
    $152–657

  4. Bus via Orlando

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus FlixBus 2421
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus Greyhound US0630
    10h
    $59–104

  5. Bus via Tampa

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Gainesvillebus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 25m
    $51–91

Fort Myers to Lake City by bus

Calendar7Weekly Buses
Duration10hAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Lake City.ExpandLaunch map view
  • Distance: 308.3 mi
  • Duration: 8h 59m

What companies run services between Fort Myers, FL, USA and Lake City, FL, USA?

You can take a vehicle from Fort Myers to Lake City Bus Station via Fort Myers 7-11, University of South Florida, Gainesville, Rosa Parks RTS Downtown Station, and Gainesville Bus Stop in around 8h 59m.

Airlines
Bus operators

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