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How to get fromFort Myers to Lexingtonby plane, bus (Flixbus, Greyhound), car, bus, or train

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There are 6 ways to get from Fort Myers to Lexington by plane, bus (Flixbus, Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia

    best
    1. Fly from Ft. Myers (RSW) to Columbia (CAE)plane plane RSW - CAE
    6h 52m
    $252–1,240

  2. Drive 563.3 mi

    cheapest
    1. Drive from Fort Myers to Lexingtoncar car 563.3 mi
    10h 56m
    $103–149

  3. Bus

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    18h 50m
    $167–279

  4. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Ft. Myers (RSW) to Greenville–Spartanburg International Airport (GSP)plane plane RSW - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Lexingtoncar car
    6h 35m
    $150–731

  5. Fly to Charleston International Airport, drive

    1. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    2. Drive from Charleston-Airport-CHS to Lexingtoncar car
    6h 27m
    $124–535

  6. Bus, train

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Take the train from Winter Park Amtrak Station to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Sumter Bus Stopbus bus
    4. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Blanding Northbus bus 44
    23h 24m
    $225–425

Ft. Myers (RSW) to Columbia (CAE) flights

Calendar91Weekly Planes
Duration5h 20mAverage Duration
Ticket$225Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Lexington.ExpandLaunch map view
  • Distance: 537.5 mi
  • Duration: 6h 52m

What companies run services between Fort Myers, FL, USA and Lexington, SC, USA?

Delta, American Airlines, and United Airlines fly from Ft. Myers (RSW) to Columbia (CAE) hourly. Alternatively, you can take a bus from Fort Myers Bus Stop to Lexington via Orlando Bus Station, Jacksonville, Camden, and Columbia, SC in around 18h 50m.

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