Rome2Rio

How to get fromFort Myers to Panama Cityby car, plane, or bus

Find Transport to Panama City

See all options

There are 7 ways to get from Fort Myers to Panama City by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 455.3 mi

    best
    1. Drive from Fort Myers to Panama Citycar car 455.3 mi
    8h 41m
    $84–120

  2. Fly Ft. Myers to Northwest Florida Beaches International Airport

    1. Fly from Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP)plane plane RSW - ECP
    7h 26m
    $158–555

  3. Bus to Sarasota–Bradenton International Airport, fly to Northwest Florida Beaches International Airport

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Northwest Florida Beaches International Airport (ECP)plane plane SRQ - ECP
    9h 14m
    $178–701

  4. Fly Ft. Myers to Destin–Fort Walton Beach Airport, drive

    1. Fly from Ft. Myers (RSW) to Destin–Fort Walton Beach Airport (VPS)plane plane RSW - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    8h 31m
    $106–503

  5. Bus to Miami International Airport, fly to Destin–Fort Walton Beach Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Destin–Fort Walton Beach Airport (VPS)plane plane MIA - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    7h 38m
    $91–387

  6. Bus to Miami International Airport, fly to Tallahassee, drive

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Tallahassee (TLH)plane plane MIA - TLH
    3. Drive from Tallahassee (TLH) to Panama Citycar car
    7h 42m
    $106–465

  7. Bus to Tampa, fly to Pensacola International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Pensacola International Airport (PNS)plane plane TPA - PNS
    3. Drive from Pensacola-Airport-PNS to Panama Citycar car
    9h 31m
    $202–505

Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar64Weekly Planes
Duration5h 33mAverage Duration
Ticket$91Cheapest Price
See schedules

Questions & Answers

Map of how to get from Fort Myers to Panama City.ExpandLaunch map view
  • Distance: 455.3 mi
  • Duration: 8h 41m

What companies run services between Fort Myers, FL, USA and Panama City, FL, USA?

Delta, Southwest Airlines, and American Airlines fly from Ft. Myers (RSW) to Northwest Florida Beaches International Airport (ECP) every 3 hours.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides