Rome2Rio

How to get fromFort Myers to Santeeby plane, car, bus (Flixbus), bus, train, or taxi

Find Transport to Santee

See all options

There are 9 ways to get from Fort Myers to Santee by plane, car, bus (Flixbus), bus, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Charleston International Airport, drive

    best
    1. Fly from Ft. Myers (RSW) to Charleston International Airport (CHS)plane plane RSW - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    5h 34m
    $114–521

  2. Drive 531.3 mi

    cheapest
    1. Drive from Fort Myers to Santeecar car 531.3 mi
    9h 21m
    $97–141

  3. Bus (Flixbus)

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus FlixBus 2421
    2. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    14h 3m
    $176–269

  4. Bus, train, drive

    1. Take the bus from Fort Myers Bus Stop to Hollywood Sheridan Trirail Stationbus bus
    2. Take the train from Fort Lauderdale Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    18h 15m
    $235–479

  5. Fly Ft. Myers to Columbia, drive

    1. Fly from Ft. Myers (RSW) to Columbia (CAE)plane plane RSW - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    7h 39m
    $234–1,221

  6. Bus to Fort Lauderdale–Hollywood International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 5m
    $202–1,152

  7. Bus to Miami International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Miami Airport Stationbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    7h 2m
    $536–1,059

  8. Bus to Tampa, fly to Charleston International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    8h 1m
    $174–395

  9. Bus, taxi

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Walterboro, SCbus bus
    4. Take the taxi from Walterboro, SC to Santeetaxi taxi
    14h 15m
    $189–284

Ft. Myers (RSW) to Charleston International Airport (CHS) flights

Calendar11Weekly Planes
Duration2h 20mAverage Duration
Ticket$100Cheapest Price
See schedules

Questions & Answers

Map of how to get from Fort Myers to Santee.ExpandLaunch map view
  • Distance: 525.6 mi
  • Duration: 5h 34m

What companies run services between Fort Myers, FL, USA and Santee, SC, USA?

You can take a bus from Fort Myers Bus Stop to Santee via Orlando Bus Station and Orangeburg in around 14h 3m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound