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How to get fromFort Myers to St. Louisby plane, bus (Flixbus, Greyhound), car, taxi, or bus

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There are 8 ways to get from Fort Myers to St. Louis by plane, bus (Flixbus, Greyhound), car, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Lambert–St. Louis International Airport

    best
    1. Fly from Ft. Myers (RSW) to Lambert–St. Louis International Airport (STL)plane plane RSW - STL
    6h 9m
    $146–708

  2. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    25h 20m
    $165–280

  3. Drive  1,106.4 mi

    1. Drive from Fort Myers to St. Louiscar car 1,106.4 mi
    18h 55m
    $202–292

  4. Taxi to Punta Gorda Airport, fly to Midamerica St. Louis Airport

    1. Take the taxi from Fort Myers to Punta Gorda Airport (PGD)taxi taxi
    2. Fly from Punta Gorda Airport (PGD) to Midamerica St. Louis Airport (BLV)plane plane PGD - BLV
    4h 6m
    $184–569

  5. Bus to Sarasota–Bradenton International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Fort Myers Bus Stop to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Lambert–St. Louis International Airport (STL)plane plane SRQ - STL
    6h 51m
    $185–922

  6. Bus to Fort Lauderdale–Hollywood International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Fort Myers Bus Stop to Fort Lauderdale International Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Lambert–St. Louis International Airport (STL)plane plane FLL - STL
    6h 48m
    $523–1,133

  7. Bus to Tampa, fly to Lambert–St. Louis International Airport

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    8h 33m
    $445–2,036

  8. Bus to Orlando, fly to Lambert–St. Louis International Airport

    1. Take the bus from Fort Myers Bus Stop to Orlandobus bus
    2. Fly from Orlando (MCO) to Lambert–St. Louis International Airport (STL)plane plane MCO - STL
    10h 43m
    $219–545

Fort Myers to St. Louis by bus

Calendar7Weekly Buses
Duration25h 20mAverage Duration
Ticket$165Cheapest Price
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Comparing Your Travel Options

Map of how to get from Fort Myers to St. Louis.ExpandLaunch map view
  • Distance: 1,009.3 mi
  • Duration: 6h 9m

What companies run services between Fort Myers, FL, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Ft. Myers (RSW) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Fort Myers Bus Stop to St Louis Bus Station via Tampa Bus Station and Atlanta Bus Station in around 25h 20m.

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