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How to get fromFort Myers to Tupeloby plane, car, bus (Flixbus, Greyhound), or bus

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There are 6 ways to get from Fort Myers to Tupelo by plane, car, bus (Flixbus, Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Golden Triangle Regional Airport, drive

    best
    1. Fly from Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR)plane plane RSW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    8h 21m
    $100–462

  2. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tupelobus bus
    19h 39m
    $125–229

  3. Drive 763.1 mi

    1. Drive from Fort Myers to Tupelocar car 763.1 mi
    14h 12m
    $140–202

  4. Bus to Tampa, fly to Birmingham–Shuttlesworth International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Birmingham–Shuttlesworth International Airport (BHM)plane plane TPA - BHM
    3. Drive from Birmingham-Airport-BHM to Tupelocar car
    9h 16m
    $145–723

  5. Fly Ft. Myers to Tupelo Regional Airport

    1. Fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP)plane plane RSW - TUP
    7h 29m
    $128–573

  6. Fly Ft. Myers to Memphis, bus

    1. Fly from Ft. Myers (RSW) to Memphis (MEM)plane plane RSW - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    11h 8m
    $180–847

Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR) flights

Calendar14Weekly Planes
Duration5h 23mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Tupelo.ExpandLaunch map view
  • Distance: 706 mi
  • Duration: 8h 21m

What companies run services between Fort Myers, FL, USA and Tupelo, MS, USA?

You can take a bus from Fort Myers Bus Stop to Tupelo via Tampa Bus Station, Atlanta Bus Station, and Tupelo in around 19h 39m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP) twice daily.

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Bus operators

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