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How to get fromFort Myers to Tupeloby plane, car, bus (Flixbus, Greyhound), or bus

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There are 6 ways to get from Fort Myers to Tupelo by plane, car, bus (Flixbus, Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Golden Triangle Regional Airport, drive

    best
    1. Fly from Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR)plane plane RSW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    8h 14m
    $88–441

  2. Bus

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tupelobus bus
    20h 9m
    $161–249

  3. Drive  763.1 mi

    1. Drive from Fort Myers to Tupelocar car 763.1 mi
    14h 12m
    $131–189

  4. Bus to Tampa, fly to Birmingham–Shuttlesworth International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Birmingham–Shuttlesworth International Airport (BHM)plane plane TPA - BHM
    3. Drive from Birmingham-Airport-BHM to Tupelocar car
    8h 36m
    $100–398

  5. Fly Ft. Myers to Tupelo Regional Airport

    1. Fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP)plane plane RSW - TUP
    8h 44m
    $102–473

  6. Fly Ft. Myers to Memphis, bus

    1. Fly from Ft. Myers (RSW) to Memphis (MEM)plane plane RSW - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    10h 58m
    $194–897

Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR) flights

Calendar14Weekly Planes
Duration4h 31mAverage Duration
Ticket$79Cheapest Price
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Comparing Your Travel Options

Map of how to get from Fort Myers to Tupelo.ExpandLaunch map view
  • Distance: 706 mi
  • Duration: 8h 14m

What companies run services between Fort Myers, FL, USA and Tupelo, MS, USA?

You can take a bus from Fort Myers Bus Stop to Tupelo via Tampa Bus Station, Atlanta Bus Station, and Tupelo in around 20h 9m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP) 3 times a day.

Airlines
Bus operators

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