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How to get fromFort Myers to Tupeloby plane, car, bus (Flixbus, Greyhound), or bus

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There are 6 ways to get from Fort Myers to Tupelo by plane, car, bus (Flixbus, Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Ft. Myers to Golden Triangle Regional Airport, drive

    best
    1. Fly from Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR)plane plane RSW - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    9h 43m
    $110–492

  2. Bus

    1. Take the bus from Fort Myers Bus Stop to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tupelobus bus
    20h 14m
    $151–285

  3. Drive 763.1 mi

    1. Drive from Fort Myers to Tupelocar car 763.1 mi
    14h 12m
    $140–202

  4. Bus to Tampa, fly to Birmingham–Shuttlesworth International Airport, drive

    1. Take the bus from Fort Myers Bus Stop to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Birmingham–Shuttlesworth International Airport (BHM)plane plane TPA - BHM
    3. Drive from Birmingham-Airport-BHM to Tupelocar car
    8h 36m
    $146–675

  5. Fly Ft. Myers to Tupelo Regional Airport

    1. Fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP)plane plane RSW - TUP
    7h 29m
    $128–573

  6. Bus via Gainesville

    1. Take the bus from Fort Myers 7-11 to University of Florida - 1956 Gale Lemerand Drbus bus
    2. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tupelobus bus
    20h 48m
    $181–332

Ft. Myers (RSW) to Golden Triangle Regional Airport (GTR) flights

Calendar22Weekly Planes
Duration6h 55mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

Map of how to get from Fort Myers to Tupelo.ExpandLaunch map view
  • Distance: 706 mi
  • Duration: 9h 43m

What companies run services between Fort Myers, FL, USA and Tupelo, MS, USA?

You can take a bus from Fort Myers Bus Stop to Tupelo via Orlando Bus Station, Atlanta Bus Station, and Tupelo in around 20h 14m. Alternatively, Southwest Airlines, Corporate Flight Management Inc, and two other airlines fly from Ft. Myers (RSW) to Tupelo Regional Airport (TUP) 3 times a day.

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Bus operators

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