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How to get fromFort Pierce to Des Moinesby plane, bus (Flixbus, Greyhound), bus, train, car, or taxi

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There are 6 ways to get from Fort Pierce to Des Moines by plane, bus (Flixbus, Greyhound), bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Vero Beach Municipal Airport

    best
    1. Fly from Vero Beach Municipal Airport (VRB) to Des Moines (DSM)plane plane VRB - DSM
    6h 24m
    $296–1,091

  2. Drive to Orlando Sanford, fly

    cheapest
    1. Drive from Fort Pierce to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    5h 33m
    $199–853

  3. Bus

    1. Take the bus from Port St Lucie to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    35h 3m
    $237–444

  4. Bus, train

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Amtrak Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    2d 8h
    $709–1,425

  5. Drive 1,427 mi

    1. Drive from Fort Pierce to Des Moinescar car 1,427 mi
    24h 39m
    $261–377

  6. Bus, taxi to Melbourne International Airport, fly

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Des Moines (DSM)plane plane MLB - DSM
    8h 50m
    $277–940

Fort Pierce to Des Moines by bus

Calendar7Weekly Buses
Duration35h 3mAverage Duration
Ticket$237Cheapest Price
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Questions & Answers

Map of how to get from Fort Pierce to Des Moines.ExpandLaunch map view
  • Distance: 1,238.6 mi
  • Duration: 6h 24m

What companies run services between Fort Pierce, FL, USA and Des Moines, IA, USA?

American Airlines flies from Vero Beach Municipal Airport (VRB) to Des Moines (DSM) twice daily. Alternatively, you can take a bus from Orange Ave & N 9th St to Des Moines via Wheeler Ter & Okeechobee Rd, Fort Pierce, Port St Lucie, Atlanta Bus Station, and St Louis Bus Station in around 35h 3m.

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