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How to get fromFort Pierce to Knoxvilleby car, plane, bus, taxi, or shuttle

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There are 7 ways to get from Fort Pierce to Knoxville by car, plane, bus, taxi, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    best
    1. Drive from Fort Pierce to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 13m
    $207–952

  2. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Fort Pierce to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 2m
    $99–417

  3. Bus, taxi, shuttle, drive

    1. Take the bus from Fort Pierce to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    24h 31m
    $380–490

  4. Drive  743.2 mi

    1. Drive from Fort Pierce to Knoxvillecar car 743.2 mi
    12h 29m
    $136–196

  5. Shuttle to Orlando, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Fort Pierce, FL - Dunkin' Donuts to Orlando Airportshuttle bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    6h 20m
    $258–953

  6. Bus, taxi to Melbourne International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Mcghee Tyson Airport (TYS)plane plane MLB - TYS
    7h 24m
    $295–1,038

  7. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Fort Lauderdale Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    6h 25m
    $261–1,105

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar13Weekly Planes
Duration1h 37mAverage Duration
Ticket$139Cheapest Price
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Comparing Your Travel Options

Map of how to get from Fort Pierce to Knoxville.ExpandLaunch map view
  • Distance: 647.1 mi
  • Duration: 4h 13m

What companies run services between Fort Pierce, FL, USA and Knoxville, TN, USA?

There is no direct connection from Fort Pierce to Knoxville. However, you can drive to Orlando-Sanford-Airport-SFB airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take the bus to Wheeler Ter & Okeechobee Rd, walk to Fort Pierce, take the bus to Jacksonville, take the bus to Charlotte Bus Station, take the bus to Boone, take the taxi to Black Bear Resort, take the shuttle to Hot Springs, drive to Chilhowee at Holston, then take the line 31 bus to Knoxville Station Hall of Fame.

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