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How to get fromFort Pierce to Knoxvilleby car, plane, bus (Greyhound, Flixbus), bus, train, shuttle, or taxi

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There are 11 ways to get from Fort Pierce to Knoxville by car, plane, bus (Greyhound, Flixbus), bus, train, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    best
    1. Drive from Fort Pierce to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 13m
    $227–1,002

  2. Drive to Orlando Sanford, fly to Asheville Regional Airport, drive

    cheapest
    1. Drive from Fort Pierce to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Asheville Regional Airport (AVL)plane plane SFB - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 2m
    $99–427

  3. Bus

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the bus from West Palm Beach Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Port Authority Bus Terminalbus bus 108
    4. Take the bus from New York to Knoxvillebus bus Nyc
    41h 20m
    $391–612

  4. Bus, train via Farragut

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 54m
    $893–1,472

  5. Drive  743.2 mi

    1. Drive from Fort Pierce to Knoxvillecar car 743.2 mi
    12h 29m
    $136–196

  6. Shuttle to Orlando, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Fort Pierce, FL - Dunkin' Donuts to Orlando Airportshuttle bus
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    6h 20m
    $268–1,003

  7. Bus, taxi to Melbourne International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Mcghee Tyson Airport (TYS)plane plane MLB - TYS
    7h 24m
    $305–1,138

  8. Bus to Fort Lauderdale–Hollywood International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Fort Lauderdale Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Mcghee Tyson Airport (TYS)plane plane FLL - TYS
    6h 25m
    $281–1,205

  9. Bus to Miami International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Fort Pierce to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Mcghee Tyson Airport (TYS)plane plane MIA - TYS
    7h 4m
    $247–1,014

  10. Bus, train

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    42h 58m
    $848–1,382

  11. Bus via Jacksonville

    1. Take the bus from Fort Pierce to Jacksonvillebus bus
    2. Take the bus from Jacksonville to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 18m
    $291–417

Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS) flights

Calendar12Weekly Planes
Duration1h 37mAverage Duration
Ticket$152Cheapest Price
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Comparing Your Travel Options

Map of how to get from Fort Pierce to Knoxville.ExpandLaunch map view
  • Distance: 647.1 mi
  • Duration: 4h 13m

What companies run services between Fort Pierce, FL, USA and Knoxville, TN, USA?

You can take a bus from Orange Ave & N 9th St to Knoxville via Wheeler Ter & Okeechobee Rd, Fort Pierce, West Palm Beach, FL, West Palm Beach Bus Station, Newark Penn Station, Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 41h 20m.

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