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How to get fromFort Pierce to Santeeby bus, plane, car, bus (Greyhound, Flixbus), train, shuttle, or taxi

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There are 9 ways to get from Fort Pierce to Santee by bus, plane, car, bus (Greyhound, Flixbus), train, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Fort Lauderdale–Hollywood International Airport, fly to Charleston International Airport, drive

    best
    1. Take the bus from Fort Pierce to Fort Lauderdale Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 47m
    $206–1,164

  2. Drive 464.5 mi

    cheapest
    1. Drive from Fort Pierce to Santeecar car 464.5 mi
    7h 35m
    $85–123

  3. Bus

    1. Take the bus from Fort Pierce to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Savannah Bus Stationbus bus
    3. Take the bus from Savannah to Orangeburgbus bus
    13h 6m

  4. Bus, train, drive

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    15h 57m
    $209–432

  5. Bus to President Donald J. Trump International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Fly from President Donald J. Trump International Airport (PBI) to Charleston International Airport (CHS)plane plane PBI - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    7h 5m
    $131–794

  6. Shuttle to Orlando, fly to Charleston International Airport, drive

    1. Take a shuttle bus from Fort Pierce, FL - Dunkin' Donuts to Orlando Airportshuttle bus
    2. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 51m
    $148–359

  7. Fly Vero Beach Municipal Airport to Charlotte Douglas International Airport, bus

    1. Fly from Vero Beach Municipal Airport (VRB) to Charlotte Douglas International Airport (CLT)plane plane VRB - CLT
    2. Take the bus from Charlotte to Orangeburgbus bus
    7h 15m

  8. Bus to Miami International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Pierce to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    7h 29m
    $543–1,076

  9. Bus, taxi to Melbourne International Airport, fly to Charlotte Douglas International Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Charlotte Douglas International Airport (CLT)plane plane MLB - CLT
    4. Take the bus from Charlotte to Orangeburgbus bus
    10h 17m

Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS) flights

Calendar27Weekly Planes
Duration3h 5mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from Fort Pierce to Santee.ExpandLaunch map view
  • Distance: 639.5 mi
  • Duration: 6h 47m

What companies run services between Fort Pierce, FL, USA and Santee, SC, USA?

You can take a bus from Orange Ave & N 9th St to Santee via Wheeler Ter & Okeechobee Rd, Fort Pierce, Jacksonville, Savannah Bus Station, Savannah, and Orangeburg in around 13h 6m.

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