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How to get fromFort Pierce to Santeeby shuttle, plane, car, bus (Greyhound, Flixbus), bus, train, taxi, or bus (Flixbus)

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There are 10 ways to get from Fort Pierce to Santee by shuttle, plane, car, bus (Greyhound, Flixbus), bus, train, taxi, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Orlando, fly to Charleston International Airport, drive

    best
    1. Take a shuttle bus from Fort Pierce, FL - Dunkin' Donuts to Orlando Airportshuttle bus
    2. Fly from Orlando (MCO) to Charleston International Airport (CHS)plane plane MCO - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 51m
    $168–359

  2. Drive  464.5 mi

    cheapest
    1. Drive from Fort Pierce to Santeecar car 464.5 mi
    7h 35m
    $85–123

  3. Bus via Jacksonville

    1. Take the bus from Fort Pierce to Jacksonvillebus bus Greyhound US0710s
    2. Take the bus from Jacksonville to Orangeburgbus bus FlixBus 2433
    12h 36m
    $158–233

  4. Bus, train, taxi via Kingstree

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Amtrak Station to Kingstree Stationtrain train
    3. Take the taxi from Kingstree Station to Santeetaxi taxi
    16h 59m
    $510–759

  5. Bus to Fort Lauderdale–Hollywood International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Pierce to Fort Lauderdale Airportbus bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    6h 49m
    $436–651

  6. Bus to Miami International Airport, fly to Charleston International Airport, drive

    1. Take the bus from Fort Pierce to Miami Airportbus bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    7h 28m
    $522–1,060

  7. Fly Vero Beach Municipal Airport to Charlotte Douglas International Airport, bus

    1. Fly from Vero Beach Municipal Airport (VRB) to Charlotte Douglas International Airport (CLT)plane plane VRB - CLT
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    7h 19m
    $265–816

  8. Bus, taxi to Melbourne International Airport, fly to Charlotte Douglas International Airport

    1. Take the bus from Fort Pierce to Sebastianbus bus
    2. Take the taxi from Sebastian to Melbourne International Airport (MLB)taxi taxi
    3. Fly from Melbourne International Airport (MLB) to Charlotte Douglas International Airport (CLT)plane plane MLB - CLT
    4. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    10h 18m
    $292–864

  9. Bus

    1. Take the bus from Fort Pierce to Orlando - RedCoach Station, FLbus bus Miami
    2. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    13h 26m
    $168–232

  10. Bus, train, taxi

    1. Take the bus from Fort Pierce to West Palm Beach, FLbus bus
    2. Take the train from West Palm Beach Amtrak Station to Denmark Amtrak Stationtrain train
    3. Take the taxi from Denmark Amtrak Station to Santeetaxi taxi
    18h 37m
    $510–799

Orlando (MCO) to Charleston International Airport (CHS) flights

Calendar14Weekly Planes
Duration2h 17mAverage Duration
Ticket$82Cheapest Price
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Comparing Your Travel Options

Map of how to get from Fort Pierce to Santee.ExpandLaunch map view
  • Distance: 494.9 mi
  • Duration: 6h 51m

What companies run services between Fort Pierce, FL, USA and Santee, SC, USA?

You can take a bus from Orange Ave & N 9th St to Santee via Wheeler Ter & Okeechobee Rd, Fort Pierce, Jacksonville, and Orangeburg in around 12h 36m.

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