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How to get fromFramingham to St. Louisby plane, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

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There are 5 ways to get from Framingham to St. Louis by plane, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL)plane plane BOS - STL
    5h 11m
    $372–862

  2. Bus

    cheapest
    1. Take the bus from South Station to Port Authority Bus Terminalbus bus Boston
    2. Take the bus from Port Authority Bus Terminal to St Louis Bus Stationbus bus Greyhound US0421
    29h 55m
    $193–381

  3. Train (Amtrak)

    1. Take the train from Framingham Amtrak to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    27h 33m
    $418–837

  4. Drive 1,132.2 mi

    1. Drive from Framingham to St. Louiscar car 1,132.2 mi
    20h 6m
    $207–299

  5. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Framingham, MA to NYC Downtownbus bus
    2. Take the bus from New York City Chinatown to Chicagobus bus
    3. Take the bus from Chicago to St Louis Bus Stationbus bus
    32h 59m
    $225–379

Framingham to St. Louis by train (Amtrak)

Calendar7Weekly Trains
Duration27h 33mAverage Duration
Ticket$418Cheapest Price
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Questions & Answers

Map of how to get from Framingham to St. Louis.ExpandLaunch map view
  • Distance: 1,080.4 mi
  • Duration: 5h 11m

What companies run services between Framingham, MA, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and United Airlines fly from Boston Logan Airport (BOS) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a train from Framingham Amtrak to St. Louis via Chicago Union Station in around 27h 33m.

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