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How to get fromFrankfurt am Main to Mayo Clinicby plane, bus, shuttle, train, or car

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There are 5 ways to get from Frankfurt am Main to Mayo Clinic by plane, bus, shuttle, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Frankfurt to Rochester

    best
    1. Fly from Frankfurt (FRA) to Rochester (RST)plane plane FRA - RST
    15h 5m
    $445–846

  2. Fly Frankfurt to Waterloo Municipal Airport, drive

    cheapest
    1. Fly from Frankfurt (FRA) to Waterloo Municipal Airport (ALO)plane plane FRA - ALO
    2. Drive from Waterloo Municipal Airport (ALO) to Mayo Cliniccar car
    17h 6m
    $354–1,236

  3. Fly Frankfurt to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Frankfurt (FRA) to Minneapolis–Saint Paul International Airport (MSP)plane plane FRA - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    14h 39m
    $546–1,258

  4. Fly Frankfurt to Mason City, bus, shuttle

    1. Fly from Frankfurt (FRA) to Mason City (MCW)plane plane FRA - MCW
    2. Take the bus from Mason City to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    19h 41m
    $366–1,386

  5. Train, train to Amsterdam Airport Schiphol, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Frankfurt to Arnhem Centraaltrain train
    2. Take the train from Arnhem Centraal to Schiphol Airport Train Stationtrain train
    3. Fly from Amsterdam Airport Schiphol (AMS) to Minneapolis–Saint Paul International Airport (MSP)plane plane AMS - MSP
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    17h 52m
    $738–1,697

Frankfurt (FRA) to Rochester (RST) flights

Calendar51Weekly Planes
Duration15h 59mAverage Duration
Ticket$325Cheapest Price
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Questions & Answers

Map of how to get from Frankfurt am Main to Mayo Clinic.ExpandLaunch map view
  • Distance: 4,419.3 mi
  • Duration: 15h 5m

What companies run services between Frankfurt am Main, Germany and Mayo Clinic, MN, USA?

Lufthansa, United Airlines, and five other airlines fly from Frankfurt (FRA) to Rochester (RST) every 4 hours.

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