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How to get fromFrankfurt am Main to Palermoby plane, train (Trenitalia), car, car ferry, bus, or train

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There are 8 ways to get from Frankfurt am Main to Palermo by plane, train (Trenitalia), car, car ferry, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Frankfurt

    best
    1. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    5h 29m
    €81–212

  2. Train

    1. Take the train from Frankfurt to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    24h 49m
    €267–1,048

  3. Drive, car ferry

    1. Drive from Frankfurt am Main to Port of Genoacar car
    2. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    28h 31m
    €224–339

  4. Bus

    1. Take the bus from Mühlheim am Main to Palermo Piazza Cairolibus bus
    30h 30m

  5. Train to Stuttgart Airport, fly

    1. Take the train from Frankfurt to Hauptbahnhoftrain train
    2. Fly from Stuttgart Airport (STR) to Palermo Airport (PMO)plane plane STR - PMO
    6h 55m
    €116–399

  6. Train to Cologne Bonn Airport, fly

    1. Take the train from Frankfurt to Siegburg Bftrain train
    2. Fly from Cologne Bonn Airport (CGN) to Palermo Airport (PMO)plane plane CGN - PMO
    6h 57m
    €98–451

  7. Bus via Rome

    1. Take the bus from Frankfurt central train station to Roma, Autostazione Tiburtinabus bus N77
    2. Take the bus from Roma, Autostazione Tiburtina to Palermobus bus N592
    35h
    €198–325

  8. Bus #2

    1. Take the bus from Frankfurt am Main - Stuttgarter Straße to Palermo Piazza Cairolibus bus
    36h 36m

Frankfurt am Main to Palermo by bus

Calendar7Weekly Buses
Duration35hAverage Duration
Ticket€198Cheapest Price
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Questions & Answers

Map of how to get from Frankfurt am Main to Palermo.ExpandLaunch map view
  • Distance: 1,411.3 km
  • Duration: 5h 29m

What companies run services between Frankfurt am Main, Germany and Palermo, Italy?

Lufthansa, ITA Airways, and Swiss fly from Frankfurt (FRA) to Palermo Airport (PMO) every 4 hours. Alternatively, you can take a train from Frankfurt to Palermo Centrale via Basel SBB, Lugano, Milano Centrale, and Roma Termini in around 24h 49m.

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