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How to get fromFrederick to Charlestonby bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or subway

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There are 6 ways to get from Frederick to Charleston by bus, plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly

    best
    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Charleston International Airport (CHS)plane plane BWI - CHS
    5h 38m
    $499–1,206

  2. Train, subway to Washington Dulles International Airport, fly

    cheapest
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Charleston International Airport (CHS)plane plane IAD - CHS
    6h 48m
    $73–438

  3. Train

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train Marc
    2. Take the train from Washington Union Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    12h 17m
    $152–342

  4. Bus

    1. Take the bus from Frederick Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Charleston Bus Stationbus bus
    17h 22m
    $101–170

  5. Drive  539.4 mi

    1. Drive from Frederick to Charlestoncar car 539.4 mi
    10h 5m
    $99–143

  6. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Charleston International Airport (CHS)plane plane DCA - CHS
    6h 4m
    $448–1,119

Frederick to Charleston by bus

Calendar7Weekly Buses
Duration17h 22mAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from Frederick to Charleston.ExpandLaunch map view
  • Distance: 547.7 mi
  • Duration: 5h 38m

What companies run services between Frederick, MD, USA and Charleston, SC, USA?

You can take a train from FREDERICK MARC eb to Charleston via Washington Union Station and Charleston Amtrak Station in around 12h 17m. Alternatively, you can take a bus from Frederick Bus Station to Transit Mall via Washington Union Station, Raleigh Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 17h 22m.

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