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How to get fromFrederick to Florenceby train (Amtrak), bus (Greyhound, Flixbus), car, bus, plane, or train

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There are 9 ways to get from Frederick to Florence by train (Amtrak), bus (Greyhound, Flixbus), car, bus, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train Marc
    2. Take the train from Washington Union Station to Florence Stationtrain train Palmetto / ...
    10h 28m
    $102–252

  2. Bus

    cheapest
    1. Take the bus from Frederick Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Florence Bus Stationbus bus
    10h 45m
    $65–116

  3. Drive  438.5 mi

    1. Drive from Frederick to Florencecar car 438.5 mi
    7h 31m
    $80–116

  4. Bus to Washington Dulles International Airport, fly to Charlotte Douglas International Airport, bus

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Charlotte Douglas International Airport (CLT)plane plane IAD - CLT
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    9h 51m
    $127–364

  5. Train, bus

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Fayetteville Bus Stationbus bus
    3. Take the train from Fayetteville Amtrak Station to Florence Stationtrain train
    11h 46m
    $68–137

  6. Bus to Baltimore-Washington International Airport, fly to Myrtle Beach, bus, train

    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Myrtle Beach (MYR)plane plane BWI - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    9h 50m
    $427–848

  7. Train to Ronald Reagan Washington National Airport, fly to Myrtle Beach, bus, train

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Myrtle Beach (MYR)plane plane DCA - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    10h 18m
    $132–581

  8. Bus to Washington Dulles International Airport, fly to Columbia, bus

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Columbia (CAE)plane plane IAD - CAE
    3. Take the bus from Columbia, SC to Camdenbus bus
    4. Take the bus from Camden to Florence Bus Stationbus bus
    10h 36m
    $98–422

  9. Bus to Washington Dulles International Airport, fly to Myrtle Beach, bus, train

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Myrtle Beach (MYR)plane plane IAD - MYR
    3. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    4. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    12h 40m
    $104–439

Frederick to Florence by train

Calendar14Weekly Trains
Duration10h 28mAverage Duration
Ticket$102Cheapest Price
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Comparing Your Travel Options

Map of how to get from Frederick to Florence.ExpandLaunch map view
  • Distance: 463 mi
  • Duration: 10h 28m

What companies run services between Frederick, MD, USA and Florence, SC, USA?

You can take a train from FREDERICK MARC eb to Florence Station via Washington Union Station in around 10h 28m. Alternatively, you can take a bus from Frederick Bus Station to Florence Bus Station via Washington Union Station and Raleigh Bus Station in around 10h 45m.

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