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How to get fromFrederick to Florida Keysby train, plane, bus (Greyhound, Flixbus), bus, car, or shuttle

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There are 12 ways to get from Frederick to Florida Keys by train, plane, bus (Greyhound, Flixbus), bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Ronald Reagan Washington National Airport, fly to Key West International Airport

    best
    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Key West International Airport (EYW)plane plane DCA - EYW
    9h 4m
    $194–711

  2. Bus to Washington Dulles International Airport, fly to Key West International Airport

    cheapest
    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Key West International Airport (EYW)plane plane IAD - EYW
    9h 19m
    $151–479

  3. Bus

    1. Take the bus from Frederick Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    30h
    $175–301

  4. Train, bus

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Fort Lauderdale Amtrak Stationtrain train
    3. Take the train from Fort Lauderdale Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    32h 54m
    $325–757

  5. Drive 1,231.6 mi

    1. Drive from Frederick to Florida Keyscar car 1,231.6 mi
    21h 5m
    $225–325

  6. Bus to Baltimore-Washington International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Miami International Airport (MIA)plane plane BWI - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 5m
    $286–678

  7. Bus to Baltimore-Washington International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the bus from Frederick Bayrunner Office to Baltimore Airportbus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane BWI - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 35m
    $371–908

  8. Train to Ronald Reagan Washington National Airport, fly to Miami International Airport, shuttle

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Miami International Airport (MIA)plane plane DCA - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    11h 1m
    $319–1,201

  9. Train to Ronald Reagan Washington National Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane DCA - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    11h 25m
    $829–1,821

  10. Bus to Washington Dulles International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane IAD - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    11h 47m
    $296–659

  11. Bus to Washington Dulles International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Miami International Airport (MIA)plane plane IAD - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    11h 30m
    $286–759

  12. Train, bus via Delray Beach

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Take the train from Rockville Amtrak to Delray Beach Amtraktrain train
    3. Take the train from Delray Beach Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    38h 36m
    $356–808

Frederick to Florida Keys by bus and foot

Calendar4Weekly Services
Duration30hAverage Duration
Ticket$175Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Florida Keys.ExpandLaunch map view
  • Distance: 1,107 mi
  • Duration: 9h 4m

What companies run services between Frederick, MD, USA and Florida Keys, FL, USA?

You can take a bus from Frederick Bus Station to Florida Keys via Washington Union Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 30h.

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