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How to get fromFrederick to Great Smoky Mountainsby bus, plane, car, or train

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There are 9 ways to get from Frederick to Great Smoky Mountains by bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport, drive

    best
    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane plane BWI - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 56m

  2. Drive 496.9 mi

    cheapest
    1. Drive from Frederick to Great Smoky Mountainscar car 496.9 mi
    9h
    $91–131

  3. Train, bus, drive

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    14h 53m
    $131–272

  4. Train, bus, drive via Danville

    1. Take the train from FREDERICK MARC eb to Washington Union Stationtrain train
    2. Take the bus from Washington Union Station to Danville Transit System Hubbus bus
    3. Take the bus from Danville to Greensborobus bus
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    18h 12m

  5. Train to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane plane DCA - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 31m
    $197–1,133

  6. Train to Ronald Reagan Washington National Airport, fly to Asheville Regional Airport, drive

    1. Take the train from FREDERICK MARC eb to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Asheville Regional Airport (AVL)plane plane DCA - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 29m
    $111–589

  7. Bus to Washington Dulles International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane plane IAD - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 31m
    $114–641

  8. Bus to Baltimore-Washington International Airport, fly to Greenville–Spartanburg International Airport, drive

    1. Take the bus from Frederick to Baltimorebus bus
    2. Fly from Baltimore-Washington International Airport (BWI) to Greenville–Spartanburg International Airport (GSP)plane plane BWI - GSP
    3. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    7h 4m

  9. Bus to Washington Dulles International Airport, fly to Greenville–Spartanburg International Airport, drive

    1. Take the bus from Frederick Transit Station to Market St & Harrison Stbus bus
    2. Fly from Washington Dulles International Airport (IAD) to Greenville–Spartanburg International Airport (GSP)plane plane IAD - GSP
    3. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    7h 48m
    $108–540

Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS) flights

Calendar22Weekly Planes
Duration2h 58mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Frederick to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 582.7 mi
  • Duration: 5h 56m

What companies run services between Frederick, MD, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Frederick to Great Smoky Mountains. However, you can take the bus to Baltimore, walk to Baltimore-Washington International Airport (BWI) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a train from FREDERICK MARC eb to Great Smoky Mountains via Washington Union Station, Greensboro, Greensboro Bus Stop, and Asheville, NC in around 14h 53m.

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